TY - JOUR
T1 - Hirano bodies accumulate C-terminal sequences of β-amyloid precursor protein (β-APP) epitopes
AU - Munoz, David G.
AU - Wang, Dequn
AU - Greenberg, Barry D.
PY - 1993/1
Y1 - 1993/1
N2 - Hirano bodies (HB) are cytoplasmic inclusions predominantly found in the CA1 sector of the hippocampus. In Alzheimer’s disease they are dislocated to the stratum pyramidale from their normal position in the stratum lacunosum. Hirano bodies are known to contain epitopes related to microfilaments (actin), neurofilaments, and microtubules (tau). In cryostat sections of the hippocampus from both Alzheimer’s disease and normal patients, HB were decorated by two antisera raised against different scquences of the cytoplasmic domain of β-amyloid precursor protein (β-APP), and two antisera against the β/A4 sequence of β-APP, but not by two antisera directed against ectodomain (N-terminal) sequences of β-APP. Thus, in contrast to dystrophic neuritcs in plaques, which are decorated by antibodies to either terminus of β-APP, HB appear to be a site of preferential accumulation of C-terminal fragments of β-APP, extending to include at least part of β/A4.
AB - Hirano bodies (HB) are cytoplasmic inclusions predominantly found in the CA1 sector of the hippocampus. In Alzheimer’s disease they are dislocated to the stratum pyramidale from their normal position in the stratum lacunosum. Hirano bodies are known to contain epitopes related to microfilaments (actin), neurofilaments, and microtubules (tau). In cryostat sections of the hippocampus from both Alzheimer’s disease and normal patients, HB were decorated by two antisera raised against different scquences of the cytoplasmic domain of β-amyloid precursor protein (β-APP), and two antisera against the β/A4 sequence of β-APP, but not by two antisera directed against ectodomain (N-terminal) sequences of β-APP. Thus, in contrast to dystrophic neuritcs in plaques, which are decorated by antibodies to either terminus of β-APP, HB appear to be a site of preferential accumulation of C-terminal fragments of β-APP, extending to include at least part of β/A4.
KW - Alzheimer’s disease
KW - Amyloid precursor protein
KW - Hirano bodies
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U2 - 10.1097/00005072-199301000-00003
DO - 10.1097/00005072-199301000-00003
M3 - Article
C2 - 7678852
AN - SCOPUS:0027498295
SN - 0022-3069
VL - 52
SP - 14
EP - 21
JO - Journal of neuropathology and experimental neurology
JF - Journal of neuropathology and experimental neurology
IS - 1
ER -