Hirano bodies accumulate C-terminal sequences of β-amyloid precursor protein (β-APP) epitopes

David G. Munoz, Dequn Wang, Barry D. Greenberg

Research output: Contribution to journalArticle

Abstract

Hirano bodies (HB) are cytoplasmic inclusions predominantly found in the CA1 sector of the hippocampus. In Alzheimer’s disease they are dislocated to the stratum pyramidale from their normal position in the stratum lacunosum. Hirano bodies are known to contain epitopes related to microfilaments (actin), neurofilaments, and microtubules (tau). In cryostat sections of the hippocampus from both Alzheimer’s disease and normal patients, HB were decorated by two antisera raised against different scquences of the cytoplasmic domain of β-amyloid precursor protein (β-APP), and two antisera against the β/A4 sequence of β-APP, but not by two antisera directed against ectodomain (N-terminal) sequences of β-APP. Thus, in contrast to dystrophic neuritcs in plaques, which are decorated by antibodies to either terminus of β-APP, HB appear to be a site of preferential accumulation of C-terminal fragments of β-APP, extending to include at least part of β/A4.

Original languageEnglish (US)
Pages (from-to)14-21
Number of pages8
JournalJournal of neuropathology and experimental neurology
Volume52
Issue number1
DOIs
StatePublished - Jan 1993
Externally publishedYes

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Keywords

  • Alzheimer’s disease
  • Amyloid precursor protein
  • Hirano bodies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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