@article{3f0ea45ab7fc4af385dbe1a1d628fe31,
title = "Hippocampal subfield volumetry from structural isotropic 1 mm3 MRI scans: A note of caution",
abstract = "Spurred by availability of automatic segmentation software, in vivo MRI investigations of human hippocampal subfield volumes have proliferated in the recent years. However, a majority of these studies apply automatic segmentation to MRI scans with approximately 1 × 1 × 1 mm3 resolution, a resolution at which the internal structure of the hippocampus can rarely be visualized. Many of these studies have reported contradictory and often neurobiologically surprising results pertaining to the involvement of hippocampal subfields in normal brain function, aging, and disease. In this commentary, we first outline our concerns regarding the utility and validity of subfield segmentation on 1 × 1 × 1 mm3 MRI for volumetric studies, regardless of how images are segmented (i.e., manually or automatically). This image resolution is generally insufficient for visualizing the internal structure of the hippocampus, particularly the stratum radiatum lacunosum moleculare, which is crucial for valid and reliable subfield segmentation. Second, we discuss the fact that automatic methods that are employed most frequently to obtain hippocampal subfield volumes from 1 × 1 × 1 mm3 MRI have not been validated against manual segmentation on such images. For these reasons, we caution against using volumetric measurements of hippocampal subfields obtained from 1 × 1 × 1 mm3 images.",
keywords = "1 mm, FreeSurfer, MRI, hippocampal subfields, volumetry",
author = "Wisse, {Laura E.M.} and Ga{\"e}l Ch{\'e}telat and Daugherty, {Ana M.} and {de Flores}, Robin and {la Joie}, Renaud and Mueller, {Susanne G.} and Stark, {Craig E.L.} and Lei Wang and Yushkevich, {Paul A.} and David Berron and Naftali Raz and Arnold Bakker and Olsen, {Rosanna K.} and Carr, {Valerie A.}",
note = "Funding Information: The authors thank David Wolk for sharing screenshots of MRI scans included in the current paper. The study was supported by Fondation Plan Alzheimer (Alzheimer Plan 2008‐2012) (GC), Programme Hospitalier de Recherche Clinique (PHRCN 2011‐A01493‐38 and PHRCN 2012 12‐006‐0347) (GC), Agence Nationale de la Recherche (LONGVIE 2007) (GC), Region Basse‐Normandie; Association France Alzheimer et maladies apparentees AAP 2013 (GC), the Fondation Philippe Chatrier (RDF), a Discovery Grant from the Natural Sciences and Engineering Research Council of Canada (NSERC; RGPIN‐2017‐06178) (RKO), a grant from the Canadian Institutes of Health (PJT‐162292) (RKO) and new investigator grant from the Alzheimer Society of Canada (RKO), National Institute of Health grants R01 AG055121 (LW), R01 EB020062 (LW), R01 AG034613 (CELS), R01 AG056014 (PY), R01 AG011230 (NR) and the donors of Alzheimer's Disease Research, a program of the BrightFocus Foundation (LEMW). Funding Information: The authors thank David Wolk for sharing screenshots of MRI scans included in the current paper. The study was supported by Fondation Plan Alzheimer (Alzheimer Plan 2008-2012) (GC), Programme Hospitalier de Recherche Clinique (PHRCN 2011-A01493-38 and PHRCN 2012 12-006-0347) (GC), Agence Nationale de la Recherche (LONGVIE 2007) (GC), Region Basse-Normandie; Association France Alzheimer et maladies apparentees AAP 2013 (GC), the Fondation Philippe Chatrier (RDF), a Discovery Grant from the Natural Sciences and Engineering Research Council of Canada (NSERC; RGPIN-2017-06178) (RKO), a grant from the Canadian Institutes of Health (PJT-162292) (RKO) and new investigator grant from the Alzheimer Society of Canada (RKO), National Institute of Health grants R01 AG055121 (LW), R01 EB020062 (LW), R01 AG034613 (CELS), R01 AG056014 (PY), R01 AG011230 (NR) and the donors of Alzheimer's Disease Research, a program of the BrightFocus Foundation (LEMW). Funding Information: Agence Nationale de la Recherche, Grant/Award Number: LONGVIE 2007; Alzheimer Society of Canada, Grant/Award Number: New investigator grant; Alzheimer's Disease Research, a program of the BrightFocus Foundation; Association France Alzheimer et maladies apparentees AAP 2013; Canadian Institutes of Health Research, Grant/Award Number: PJT‐162292; Discovery Grant from the Natural Sciences and Engineering Research Council of Canada, Grant/Award Number: RGPIN‐2017‐06178; Fondation Plan Alzheimer, Grant/Award Number: Alzheimer Plan 2008‐2012; National Institutes of Health, Grant/Award Numbers: AG011230, AG034613, AG055121, AG056014, EB020062; Programme Hospitalier de Recherche Clinique, Grant/Award Numbers: PHRCN 2011‐A01493‐38, PHRCN 2012 12‐006‐0347; the Fondation Philippe Chatrier Funding information Publisher Copyright: {\textcopyright} 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.",
year = "2021",
month = feb,
day = "1",
doi = "10.1002/hbm.25234",
language = "English (US)",
volume = "42",
pages = "539--550",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "2",
}