Hippocampal lesions interfere with long-trace taste aversion conditioning

Ming Teng Koh, Daniel S. Wheeler, Michela Gallagher

Research output: Contribution to journalArticle

Abstract

This series of experiments investigated the effects of dorsal and ventral hippocampal lesions on taste aversion learning. Although damage to the hippocampus did not affect the acquisition of a taste aversion when the conditioning procedure used a relatively standard interval between taste and illness, both types of lesions produced a deficit in taste aversion when a long interval (3 h) was interposed between taste exposure and induction of illness. In the same subjects, trace fear conditioning was selectively impaired by ventral lesions, whereas water maze performance was selectively impaired by dorsal lesions. The results replicate past dissociations of dorsal and ventral hippocampal function, and also suggest that the hippocampus has a less differentiated role in long-trace taste aversion learning.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalPhysiology and Behavior
Volume98
Issue number1-2
DOIs
Publication statusPublished - Aug 4 2009

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Keywords

  • Delay
  • Freezing
  • Memory
  • Spatial
  • Trace

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology

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