Hindbrain GRP receptor blockade antagonizes feeding suppression by peripherally administered GRP

Ellen E. Ladenheim, John E. Taylor, David H. Coy, Kimberly A. Moore, Timothy H. Moran

Research output: Contribution to journalArticlepeer-review

Abstract

Bombesin (BN)-like peptides injected peripherally or centrally suppress food intake in rats. The relationship between the central and peripheral actions of BN is unknown. However, experimental evidence supports a critical role for the caudal hindbrain in mediating the feeding effects of BN. To investigate this relationship further, we examined the ability of fourth ventricular infusion of a specific gastrin-releasing peptide (GRP) antagonist, (D-F5,Phe6,D-Ala11]BN-(613)methyl ester (BN-ME), to block suppression of glucose intake (0.5 kcal/ml) produced by intraperitoneal administration of GRP-(18-27) in 5-h food-deprived male Sprague-Dawley rats (n = 10). We found that fourth ventricular administration of 10, 32, and 100 ng BN-ME blocked the suppression of glucose intake produced by peripherally administered 10 nmol/kg GRP-(18-27). The most effective dose of BN-ME (100 ng) blocked the ability of peripheral injection of GRP-(18-27) to inhibit glucose intake but had no effect on intake when given alone. These results demonstrate that the availability of caudal hindbrain GRP receptors is necessary for peripherally administered GRP-(18-27) to reduce food intake in rats.

Original languageEnglish (US)
Pages (from-to)R180-R184
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume271
Issue number1 40-1
DOIs
StatePublished - Jul 1996

Keywords

  • bombesin
  • caudal hindbrain
  • ingestion
  • neuromedin C
  • satiety

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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