Hindbrain GABA receptors influence parasympathetic outflow to the stomach

Daniel J. Williford, Herbert S. Ormsbee, Wesley Norman, John W. Harmon, Thomas Q. Garvey, Joseph A. Dimicco, Richard A. Gillis

Research output: Contribution to journalArticlepeer-review

Abstract

Blockade of γ-aminobutyric acid receptor function by direct microinjection of bicuculline into the nucleus ambiguus in cats produced a marked increase in gastric motility which was mediated by the vagus nerve. This effect was reversed by muscimol. These data indicate that the nucleus ambiguus may be an important brain site influencing gastric function and that the neurotransmitter controlling parasympathetic outflow from this nucleus to the stomach is γ-aminobutyric acid.

Original languageEnglish (US)
Pages (from-to)193-194
Number of pages2
JournalScience
Volume214
Issue number4517
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • General

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