Hilar cholangiocarcinoma: Tumor depth as a predictor of outcome

Mechteld C. De Jong, Seung Mo Hong, Mathew M. Augustine, Michael S Goggins, Christopher Wolfgang, Kenzo Hirose, Richard D. Schulick, Michael A. Choti, Robert A Anders, Timothy M. Pawlik

Research output: Contribution to journalArticle


Background: The American Joint Committee on Cancer staging system for hilar cholangiocarcinoma may be inaccurate because the bile duct lacks discrete tissue boundaries. Objectives: To examine the accuracy of the American Joint Committee on Cancer staging schemes and to determine the prognostic implications of tumor depth. Design, Setting, and Patients: From January 1, 1987, through December 31, 2009, there were 106 patients who underwent resection of hilar cholangiocarcinoma who had pathologic slides available for re-review. Main Outcome Measures: Tumor depth and overall survival. Results: Overall median survival was 19.9 months. The 6th and 7th editions of the T-classification criteria were unable to discriminate among T1, T2, and T3 lesions (P>.05 for all). Median survival was associated with the invasion depth of the tumor (≥5 mm vs

Original languageEnglish (US)
Pages (from-to)697-703
Number of pages7
JournalArchives of Surgery
Issue number6
StatePublished - Jun 2011


ASJC Scopus subject areas

  • Surgery

Cite this

De Jong, M. C., Hong, S. M., Augustine, M. M., Goggins, M. S., Wolfgang, C., Hirose, K., Schulick, R. D., Choti, M. A., Anders, R. A., & Pawlik, T. M. (2011). Hilar cholangiocarcinoma: Tumor depth as a predictor of outcome. Archives of Surgery, 146(6), 697-703. https://doi.org/10.1001/archsurg.2011.122