Highly purified lipoteichoic acid from Staphylococcus aureus induces procoagulant activity and tissue factor expression in human monocytes but is a weak inducer in whole blood: Comparison with peptidoglycan

Eva Mattsson, Thomas Hartung, Siegfried Morath, Arne Egesten

Research output: Contribution to journalArticlepeer-review

Abstract

Lipoteichoic acid from Staphylococcus aureus was a potent inducer of procoagulant activity in isolated mononuclear cells but not in whole blood. In contrast, staphylococcal peptidoglycan showed equal levels of potency in isolated mononuclear cells and whole blood, suggesting that peptidoglycan is an important inducer of procoagulant activity in severe sepsis involving gram-positive bacteria.

Original languageEnglish (US)
Pages (from-to)4322-4326
Number of pages5
JournalInfection and immunity
Volume72
Issue number7
DOIs
StatePublished - Jul 2004
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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