Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluation

Kewal Kumar, Sarah Schniper, Antonio González-Sarrías, Alvin A. Holder, Natalie Sanders, David Sullivan, William L. Jarrett, Krystyn Davis, Fengwei Bai, Navindra P. Seeram, Vipan Kumar

Research output: Contribution to journalArticle

Abstract

A gallium(III) complex with 7-chloroquinoline thiosemicarbazone was synthesized and characterized. The complex proved to be thirty-one times more potent on colon cancer cell line, HCT-116, with considerably less cytotoxicity on non-cancerous colon fibroblast, CCD-18Co, when compared to etoposide. Its anti-malarial potential on 3D7 isolate of Plasmodium falciparum was better than lumefantrine.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Volume86
DOIs
StatePublished - Oct 30 2014

Keywords

  • 7-Chloroquinoline thiosemicarbazone
  • Anti-plasmodial activity
  • Cytotoxic activity
  • Gallium(III) complex
  • Selectivity index

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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