Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluation

Kewal Kumar; Sarah Schniper; Antonio González-Sarrías; Alvin A. Holder; Natalie Sanders; David Sullivan; William L. Jarrett; Krystyn Davis; Fengwei Bai; Navindra P. Seeram; Vipan Kumar

doi:10.1016/j.ejmech.2014.08.054

Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluation

Kewal Kumar, Sarah Schniper, Antonio González-Sarrías, Alvin A. Holder, Natalie Sanders, David Sullivan, William L. Jarrett, Krystyn Davis, Fengwei Bai, Navindra P. Seeram, Vipan Kumar

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A gallium(III) complex with 7-chloroquinoline thiosemicarbazone was synthesized and characterized. The complex proved to be thirty-one times more potent on colon cancer cell line, HCT-116, with considerably less cytotoxicity on non-cancerous colon fibroblast, CCD-18Co, when compared to etoposide. Its anti-malarial potential on 3D7 isolate of Plasmodium falciparum was better than lumefantrine.

Original language	English (US)
Pages (from-to)	81-86
Number of pages	6
Journal	European Journal of Medicinal Chemistry
Volume	86
DOIs	https://doi.org/10.1016/j.ejmech.2014.08.054
State	Published - Oct 30 2014

Keywords

7-Chloroquinoline thiosemicarbazone
Anti-plasmodial activity
Cytotoxic activity
Gallium(III) complex
Selectivity index

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Organic Chemistry

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10.1016/j.ejmech.2014.08.054

Cite this

Kumar, K., Schniper, S., González-Sarrías, A., Holder, A. A., Sanders, N., Sullivan, D., Jarrett, W. L., Davis, K., Bai, F., Seeram, N. P., & Kumar, V. (2014). Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluation. European Journal of Medicinal Chemistry, 86, 81-86. https://doi.org/10.1016/j.ejmech.2014.08.054

Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluation. / Kumar, Kewal; Schniper, Sarah; González-Sarrías, Antonio et al.
In: European Journal of Medicinal Chemistry, Vol. 86, 30.10.2014, p. 81-86.

Research output: Contribution to journal › Article › peer-review

Kumar, K, Schniper, S, González-Sarrías, A, Holder, AA, Sanders, N, Sullivan, D, Jarrett, WL, Davis, K, Bai, F, Seeram, NP & Kumar, V 2014, 'Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluation', European Journal of Medicinal Chemistry, vol. 86, pp. 81-86. https://doi.org/10.1016/j.ejmech.2014.08.054

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title = "Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluation",

abstract = "A gallium(III) complex with 7-chloroquinoline thiosemicarbazone was synthesized and characterized. The complex proved to be thirty-one times more potent on colon cancer cell line, HCT-116, with considerably less cytotoxicity on non-cancerous colon fibroblast, CCD-18Co, when compared to etoposide. Its anti-malarial potential on 3D7 isolate of Plasmodium falciparum was better than lumefantrine.",

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author = "Kewal Kumar and Sarah Schniper and Antonio Gonz{\'a}lez-Sarr{\'i}as and Holder, {Alvin A.} and Natalie Sanders and David Sullivan and Jarrett, {William L.} and Krystyn Davis and Fengwei Bai and Seeram, {Navindra P.} and Vipan Kumar",

note = "Funding Information: Financial assistance from DST, New Delhi, under INSPIRE Fellowship (KK) with code- IF-10482 is gratefully acknowledged. An NCCR grant GCRC RR0052 supported the culturing of P. falciparum for the production of malaria parasites. ",

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doi = "10.1016/j.ejmech.2014.08.054",

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AU - Schniper, Sarah

AU - González-Sarrías, Antonio

AU - Holder, Alvin A.

AU - Sanders, Natalie

AU - Sullivan, David

AU - Jarrett, William L.

AU - Davis, Krystyn

AU - Bai, Fengwei

AU - Seeram, Navindra P.

AU - Kumar, Vipan

N1 - Funding Information: Financial assistance from DST, New Delhi, under INSPIRE Fellowship (KK) with code- IF-10482 is gratefully acknowledged. An NCCR grant GCRC RR0052 supported the culturing of P. falciparum for the production of malaria parasites.

PY - 2014/10/30

Y1 - 2014/10/30

N2 - A gallium(III) complex with 7-chloroquinoline thiosemicarbazone was synthesized and characterized. The complex proved to be thirty-one times more potent on colon cancer cell line, HCT-116, with considerably less cytotoxicity on non-cancerous colon fibroblast, CCD-18Co, when compared to etoposide. Its anti-malarial potential on 3D7 isolate of Plasmodium falciparum was better than lumefantrine.

AB - A gallium(III) complex with 7-chloroquinoline thiosemicarbazone was synthesized and characterized. The complex proved to be thirty-one times more potent on colon cancer cell line, HCT-116, with considerably less cytotoxicity on non-cancerous colon fibroblast, CCD-18Co, when compared to etoposide. Its anti-malarial potential on 3D7 isolate of Plasmodium falciparum was better than lumefantrine.

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KW - Cytotoxic activity

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KW - Selectivity index

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Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluation

Abstract

Keywords

ASJC Scopus subject areas

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