@article{029beb48a7d5406e8ac656b5c3558969,
title = "Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver",
abstract = "Studies of human hepatitis B virus (HBV) immune pathogenesis are hampered by limited access to liver tissues and technologies for detailed analyses. Here, utilizing imaging mass cytometry (IMC) to simultaneously detect 30 immune, viral, and structural markers in liver biopsies from patients with hepatitis B e antigen+ (HBeAg+) chronic hepatitis B, we provide potentially novel comprehensive visualization, quantitation, and phenotypic characterizations of hepatic adaptive and innate immune subsets that correlated with hepatocellular injury, histological fibrosis, and age. We further show marked correlations between adaptive and innate immune cell frequencies and phenotype, highlighting complex immune interactions within the hepatic microenvironment with relevance to HBV pathogenesis.",
author = "Daniel Traum and Wang, {Yue J.} and Schwarz, {Kathleen B.} and Jonathan Schug and Wong, {David K.H.} and Janssen, {Harry L.A.} and Terrault, {Norah A.} and Mandana Khalili and Wahed, {Abdus S.} and Murray, {Karen F.} and Phillip Rosenthal and Ling, {Simon C.} and Norberto Rodriguez-Baez and Sterling, {Richard K.} and Lau, {Daryl T.Y.} and Block, {Timothy M.} and Feldman, {Michael D.} and Furth, {Elizabeth E.} and Lee, {William M.} and Kleiner, {David E.} and Lok, {Anna S.} and Kaestner, {Klaus H.} and Chang, {Kyong Mi}",
note = "Funding Information: The authors acknowledge the use of HBRN data and liver biopsy samples from the HBRN, with additional support in data analyses from the HBRN Data Coordinating Center (DK082864) and NIH/NIDDK Central Repository. Additional funding support for this work includes: DK082864 and NIDDK P30 Center for Molecular Studies in Digestive and Liver Disease Supplement Supplemental Funding (DK082866); Hepatitis B Foundation; and the Corporal Michael J. Crescenz VA Medical Center. Publisher Copyright: {\textcopyright} 2021, Traum et al.",
year = "2021",
month = apr,
day = "8",
doi = "10.1172/jci.insight.146883",
language = "English (US)",
volume = "6",
journal = "JCI Insight",
issn = "2379-3708",
publisher = "The American Society for Clinical Investigation",
number = "7",
}