Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability

Paul Thiam Joo Tan, Asif M. Khan, J. Thomas August

Research output: Contribution to journalReview articlepeer-review

Abstract

Vaccines are the only proven effective method for prevention of human infectious diseases. Almost all traditional vaccines require activating immunological memory B cells to secrete neutralizing antibodies against invading pathogens. The complication with influenza viruses is the high viral mutation rate that results in immune escape through modification of the B cell epitopes. Studies of T cell immunity to influenza infection provide an alternative vaccine strategy based on highly conserved T cell epitopes. In this review, we discuss the importance of T cell-mediated immunity in influenza infection and the need for a targeted vaccine approach focused on highly conserved T cell epitopes to mitigate immune escape. We propose 15 highly conserved pan-influenza sequences as potential T cell epitopes-based vaccine targets for broad protection and lasting immunity against variant influenza strains.

Original languageEnglish (US)
JournalHuman vaccines
Volume7
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • Altered peptide ligands
  • High conservation
  • Immunodominance
  • Immunoinformatics
  • Pan-influenza
  • Pandemic H1N1
  • T cell epitopes-based vaccine

ASJC Scopus subject areas

  • Immunology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability'. Together they form a unique fingerprint.

Cite this