Highly attenuated infection with a VPR-deleted molecular clone of human immunodeficiency virus-1

Ayub Ali, Hwee L. Ng, Joel N. Blankson, Dennis R. Burton, Robert W. Buckheit, Brian Moldt, Jennifer A. Fulcher, F. Javier Ibarrondo, Peter A. Anton, Otto O. Yang

Research output: Contribution to journalArticlepeer-review

Abstract

A 48-year-old woman was infected with a vpr-defective human immunodeficiency virus (HIV)-1 molecular clone. Seroconversion was markedly delayed, and without treatment she had durably suppressed viremia and normal T-cell levels. Neutralizing antibody and CD8+ T-cell immune responses against HIV-1 were unremarkable. Viral sequences confirmed the source but evolved defective nef, suggesting an unknown mechanistic link to vpr. There were subtle qualitative defects in T and B cells. To our knowledge, this is the only case of human infection with a characterized defective HIV-1 molecular clone, which furthermore recapitulated live-attenuated vaccination in macaque models of HIV-1 vaccine research.

Original languageEnglish (US)
Pages (from-to)1447-1452
Number of pages6
JournalJournal of Infectious Diseases
Volume218
Issue number9
DOIs
StatePublished - Sep 22 2018

Keywords

  • Elite control
  • HIV-1
  • Vpr

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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