Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1α,25-dihydroxyvitamin D3

Sandra Sinishtaj, Heung Bae Jeon, Patrick Dolan, Thomas W. Kensler, Gary H. Posner

Research output: Contribution to journalArticle

Abstract

Four new side-chain amide (2 and 3) and hydroxamate (4 and 5) analogs of the hormone calcitriol (1) have been prepared. Even though lacking the 25-OH group characteristic of natural calcitriol (1), analogs 2-4 are as antiproliferative in vitro as calcitriol (1) but are 20-40 times less calciuric in vivo than calcitriol (1).

Original languageEnglish (US)
Pages (from-to)6341-6348
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume14
Issue number18
DOIs
StatePublished - Sep 15 2006

Keywords

  • Antiproliferative
  • Calcitriol
  • Vitamin D

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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