Highlights of the first international "immunotherapy in pediatric oncology: Progress and challenges" meeting

Christian M. Capitini, Laurence J.N. Cooper, R. Maarten Egeler, Rupert Handgretinger, Franco Locatelli, Paul M. Sondel, Crystal L. MacKall

Research output: Contribution to journalArticle

Abstract

The first annual conference on immunotherapy in pediatric oncology was held in Bethesda, MD, from September 9 to 10, 2008 to discuss the state-of-the-art of immunotherapeutic strategies currently being explored in pediatric oncology. Major topics included targeting cell surface receptors, understanding and improving T-cell-based therapies, augmenting innate immune strategies, and enhancing graft-versus-leukemia for pediatric malignancies. As can be seen in the summaries of the individual presentations, significant progress has been made in developing preclinical models of pediatric tumors and a variety of novel immunobiologic therapies are approaching, or already in, the clinic. Although there is much excitement about the potential utility of these agents, a great deal of challenges lie ahead in improving the efficacy of each of these modalities and getting them to patients in a timely fashion. The resulting discussions will hopefully lead to new collaborations and insight for further translational and clinical studies.

Original languageEnglish (US)
Pages (from-to)227-244
Number of pages18
JournalJournal of Pediatric Hematology/Oncology
Volume31
Issue number4
DOIs
StatePublished - Apr 2009

Keywords

  • Cell surface receptors
  • Graft-versus-leukemia
  • Immunotherapy
  • Innate immunity
  • T cells

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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    Capitini, C. M., Cooper, L. J. N., Maarten Egeler, R., Handgretinger, R., Locatelli, F., Sondel, P. M., & MacKall, C. L. (2009). Highlights of the first international "immunotherapy in pediatric oncology: Progress and challenges" meeting. Journal of Pediatric Hematology/Oncology, 31(4), 227-244. https://doi.org/10.1097/MPH.0b013e31819a5d8d