Highlights of the Biology and Disease-driven Human Proteome Project, 2015-2016

Jennifer E. Van Eyk, Fernando J. Corrales, Ruedi Aebersold, Ferdinando Cerciello, Eric W. Deutsch, Paola Roncada, Jean Charles Sanchez, Tadashi Yamamoto, Pengyuan Yang, Hui Zhang, Gilbert S. Omenn

Research output: Contribution to journalReview article

Abstract

The Biology and Disease-driven Human Proteome Project (B/D-HPP) is aimed at supporting and enhancing the broad use of state-of-the-art proteomic methods to characterize and quantify proteins for in-depth understanding of the molecular mechanisms of biological processes and human disease. Based on a foundation of the pre-existing HUPO initiatives begun in 2002, the B/D-HPP is designed to provide standardized methods and resources for mass spectrometry and specific protein affinity reagents and facilitate accessibility of these resources to the broader life sciences research and clinical communities. Currently there are 22 B/D-HPP initiatives and 3 closely related HPP resource pillars. The B/D-HPP groups are working to define sets of protein targets that are highly relevant to each particular field to deliver relevant assays for the measurement of these selected targets and to disseminate and make publicly accessible the information and tools generated. Major developments are the 2016 publications of the Human SRM Atlas and of "popular protein sets" for six organ systems. Here we present the current activities and plans of the BD-HPP initiatives as highlighted in numerous B/D-HPP workshops at the 14th annual HUPO 2015 World Congress of Proteomics in Vancouver, Canada.

Original languageEnglish (US)
Pages (from-to)3979-3987
Number of pages9
JournalJournal of proteome research
Volume15
Issue number11
DOIs
StatePublished - Nov 4 2016

Keywords

  • B/D-HPP
  • Biology and Disease-driven Human Proteome Project
  • MS
  • SRM-MS
  • mass spectrometry
  • selected reaction monitoring-MS

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)

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  • Cite this

    Van Eyk, J. E., Corrales, F. J., Aebersold, R., Cerciello, F., Deutsch, E. W., Roncada, P., Sanchez, J. C., Yamamoto, T., Yang, P., Zhang, H., & Omenn, G. S. (2016). Highlights of the Biology and Disease-driven Human Proteome Project, 2015-2016. Journal of proteome research, 15(11), 3979-3987. https://doi.org/10.1021/acs.jproteome.6b00444