Higher Time-updated Body Mass Index: Association with Improved CD4+ Cell Recovery on HIV Treatment

John R. Koethe, Cathy A. Jenkins, Bryan M Lau, Bryan E. Shepherd, William Wester, Peter F. Rebeiro, Michael J. Silverberg, Jennifer Thorne, John Gill, Angel M. Mayor, Amanda Willig, Ronald Bosch, Michael A. Horberg, Amy C. Justice, Timothy R. Sterling, Richard D Moore

Research output: Contribution to journalArticle

Abstract

BACKGROUND:: Prior studies found overweight or obese HIV-infected individuals had greater early CD4+ cell recovery on antiretroviral therapy (ART), but the results have been inconsistent. We assessed the longitudinal relationship between body mass index (BMI) and CD4+ cell recovery on ART in a large, multi-site cohort to identify potential physiologic links between adiposity and CD4+ cell expansion. METHODS:: We modeled the relationship of time-updated BMI with CD4+ count in patients starting ART from 17 North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) cohorts. The primary analysis used a linear mixed effects model incorporating up to 13 years of data per patient and adjusted for age, sex, race, ART regimen, baseline CD4+ count and other covariates. Sensitivity analyses limited the cohort to patients with sustained viral suppression or censored at virologic failure. RESULTS:: 14,084 HIV-infected individuals initiating ART contributed data between 1998 and 2010. Time-updated BMI was significantly associated with CD4+ cell recovery over time (p

Original languageEnglish (US)
JournalJournal of Acquired Immune Deficiency Syndromes
DOIs
StateAccepted/In press - Apr 21 2016

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ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Koethe, J. R., Jenkins, C. A., Lau, B. M., Shepherd, B. E., Wester, W., Rebeiro, P. F., Silverberg, M. J., Thorne, J., Gill, J., Mayor, A. M., Willig, A., Bosch, R., Horberg, M. A., Justice, A. C., Sterling, T. R., & Moore, R. D. (Accepted/In press). Higher Time-updated Body Mass Index: Association with Improved CD4+ Cell Recovery on HIV Treatment. Journal of Acquired Immune Deficiency Syndromes. https://doi.org/10.1097/QAI.0000000000001035