Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture

Christopher R. D'Adamo, Ram R. Miller, Michelle D. Shardell, Denise L. Orwig, Marc C. Hochberg, Luigi Ferrucci, Richard David Semba, Janet A. Yu-Yahiro, Jay Magaziner, Gregory E. Hicks

Research output: Contribution to journalArticle

Abstract

Background & aims: Chronic inflammation impairs recovery among the 1.6 million people who suffer from hip fracture annually. Vitamin E and the carotenoids are two classes of dietary antioxidants with profound anti-inflammatory effects, and the goal of this study was to assess whether higher post-fracture concentrations of these antioxidants were associated with lower levels of interleukin 6 (IL-6) and the soluble receptor for tumor necrosis factor-alpha (sTNF-αR1), two common markers of inflammation. Methods: Serum concentrations of the dietary antioxidants and inflammatory markers were assessed at baseline and 2, 6, and 12 month follow-up visits among 148 hip fracture patients from The Baltimore Hip Studies. Generalized estimating equations modeled the relationship between baseline and time-varying antioxidant concentrations and inflammatory markers. Results: Higher post-fracture concentrations of vitamin E and the carotenoids were associated with lower levels of inflammatory markers. Associations were strongest at baseline, particularly between the α-tocopherol form of vitamin E and sTNF-αR1 (p = 0.05) and total carotenoids and both sTNF-αR1(p = 0.01) and IL-6 (p = 0.05). Higher baseline and time-varying α-carotene and time-varying lutein concentrations were also associated with lower sTNF-αR1 at all post-fracture visits (p ≤ 0.05). Conclusions: These findings suggest that a clinical trial increasing post-fracture intake of vitamin E and the carotenoids may be warranted.

Original languageEnglish (US)
Pages (from-to)659-665
Number of pages7
JournalClinical Nutrition
Volume31
Issue number5
DOIs
StatePublished - Oct 2012

Fingerprint

Hip Fractures
Carotenoids
Vitamin E
Antioxidants
Biomarkers
Serum
Inflammation
Interleukin-6 Receptors
Lutein
Baltimore
Tocopherols
Hip
Interleukin-6
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Clinical Trials

Keywords

  • Antioxidants
  • Carotenoids
  • Hip fracture
  • Inflammation
  • Micronutrients
  • Vitamin E

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

Cite this

D'Adamo, C. R., Miller, R. R., Shardell, M. D., Orwig, D. L., Hochberg, M. C., Ferrucci, L., ... Hicks, G. E. (2012). Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture. Clinical Nutrition, 31(5), 659-665. https://doi.org/10.1016/j.clnu.2012.01.013

Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture. / D'Adamo, Christopher R.; Miller, Ram R.; Shardell, Michelle D.; Orwig, Denise L.; Hochberg, Marc C.; Ferrucci, Luigi; Semba, Richard David; Yu-Yahiro, Janet A.; Magaziner, Jay; Hicks, Gregory E.

In: Clinical Nutrition, Vol. 31, No. 5, 10.2012, p. 659-665.

Research output: Contribution to journalArticle

D'Adamo, CR, Miller, RR, Shardell, MD, Orwig, DL, Hochberg, MC, Ferrucci, L, Semba, RD, Yu-Yahiro, JA, Magaziner, J & Hicks, GE 2012, 'Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture', Clinical Nutrition, vol. 31, no. 5, pp. 659-665. https://doi.org/10.1016/j.clnu.2012.01.013
D'Adamo, Christopher R. ; Miller, Ram R. ; Shardell, Michelle D. ; Orwig, Denise L. ; Hochberg, Marc C. ; Ferrucci, Luigi ; Semba, Richard David ; Yu-Yahiro, Janet A. ; Magaziner, Jay ; Hicks, Gregory E. / Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture. In: Clinical Nutrition. 2012 ; Vol. 31, No. 5. pp. 659-665.
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AU - Hochberg, Marc C.

AU - Ferrucci, Luigi

AU - Semba, Richard David

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