TY - JOUR
T1 - Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE consortium studies1-4
AU - Hruby, Adela
AU - Ngwa, Julius S.
AU - Renström, Frida
AU - Mary, Mary K.
AU - Ganna, Andrea
AU - Hallmans, Göran
AU - Houston, Denise K.
AU - Jacques, Paul F.
AU - Kanoni, Stavroula
AU - Lehtimäki, Terho
AU - Lemaitre, Rozenn N.
AU - Manichaikul, Ani
AU - North, Kari E.
AU - Ntalla, Ioanna
AU - Sonestedt, Emily
AU - Tanaka, Toshiko
AU - van Rooij, Frank J.A.
AU - Bandinelli, Stefania
AU - Djoussé, Luc
AU - Grigoriou, Efi
AU - Johansson, Ingegerd
AU - Lohman, Kurt K.
AU - Pankow, James S.
AU - Raitakari, Olli T.
AU - Riserus, Ulf
AU - Yannakoulia, Mary
AU - Zillikens, M. Carola
AU - Hassanali, Neelam
AU - Liu, Yongmei
AU - Mozaffarian, Dariush
AU - Papoutsakis, Constantina
AU - Syvänen, Ann Christine
AU - Uitterlinden, André G.
AU - Viikari, Jorma
AU - Groves, Christopher J.
AU - Lind, Albert Hofman
AU - Lind, Lars
AU - McCarthy, Mark I.
AU - Mikkilä̈, Vera
AU - Mukamal, Kenneth
AU - Franco, Oscar H.
AU - Borecki, Ingrid B.
AU - Cupples, L. Adrienne
AU - Dedoussis, George V.
AU - Ferrucci, Luigi
AU - Hu, Frank B.
AU - Ingelsson, Erik
AU - Kähönen, Mika
AU - Kao, W. H.Linda
AU - Kritchevsky, Stephen B.
AU - Orho-Melander, Marju
AU - Prokopenko, Inga
AU - Rotter, Jerome I.
AU - Siscovick, David S.
AU - Witteman, Jacqueline C.M.
AU - Franks, Paul W.
AU - Meigs, James B.
AU - McKeown, Nicola M.
AU - Nettleton, Jennifer A.
PY - 2013/3
Y1 - 2013/3
N2 - Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesiumintake and fasting glucose and insulin. Fifteen studies fromthe CHARGE (Cohorts for Heart and Aging Research inGenomic Epidemiology) Consortiumprovided data fromup to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (ln-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [β = 20.009 mmol/L (95% CI: 20.013, 20.005), P < 0.0001] and insulin [20.020 ln-pmol/L (95%CI:20.024,20.017), P < 0.0001].Nomagnesium-related SNP or interaction between any SNP andmagnesiumreached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose, and rs11558471 in SLC30A8 and rs3740393 near CNNM2 showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted.
AB - Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesiumintake and fasting glucose and insulin. Fifteen studies fromthe CHARGE (Cohorts for Heart and Aging Research inGenomic Epidemiology) Consortiumprovided data fromup to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (ln-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [β = 20.009 mmol/L (95% CI: 20.013, 20.005), P < 0.0001] and insulin [20.020 ln-pmol/L (95%CI:20.024,20.017), P < 0.0001].Nomagnesium-related SNP or interaction between any SNP andmagnesiumreached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose, and rs11558471 in SLC30A8 and rs3740393 near CNNM2 showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted.
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U2 - 10.3945/jn.112.172049
DO - 10.3945/jn.112.172049
M3 - Article
C2 - 23343670
AN - SCOPUS:84874705274
SN - 0022-3166
VL - 143
SP - 345
EP - 353
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 3
ER -