Higher incidence of diabetes in liver transplant recipients with hepatitis C

Hilla Knobler, Alex Stagnaro-Green, Sylvan Wallenstein, Myron Schwartz, Sheila H. Roman

Research output: Contribution to journalArticle

Abstract

We assessed the clinical and biochemical parameters associated with the development of posttransplantation diabetes (PTDM) in 52 liver transplant recipients followed up for 1 year. Diabetes was present before transplantation in 9.6% (5 of 52) of patients, and PTDM occurred in 23% (11 of 47) of the remaining liver transplant recipients. Of the 13 patients who had hepatitis C as the cause of their liver failure (HC-LD), 8 (62%) developed PTDM; of the 34 patients with other causes of liver failure, 3 (9%) developed PTDM (p < 0.001). Posttransplantation diabetes was also associated with the development of early posttransplantation hyperglycemia, a higher number of liver rejection episodes, and lower serum albumin levels at 6 months. The association of PTDM with HC-LD remained significant in a logistic regression model after adjustment for potential confounding variables. We conclude that PTDM is common in liver transplant recipients. Associated clinical parameters predictive of PTDM include a diagnosis of HC-LD before transplantation, the development of early hyperglycemia after transplantation, multiple episodes of posttransplantation liver rejection and low serum albumin levels at 6 months. The fact that HC-LD remained an independent risk factor for the development of PTDM may suggest a direct or immune-mediated pancreatic effect of the virus.

Original languageEnglish (US)
Pages (from-to)30-33
Number of pages4
JournalJournal of clinical gastroenterology
Volume26
Issue number1
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Keywords

  • Diabetes mellitus
  • Hepatitis C
  • Liver transplantation

ASJC Scopus subject areas

  • Gastroenterology

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