Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states

Chuan V. Dang, Chi V. Dang

Research output: Contribution to journalArticlepeer-review

Abstract

The aminoacyl-tRNA synthetases play a dual role in cell metabolism by synthesizing aminoacyl-tRNAs and an odd dinucleotide diadenosine-5′, 5′′′-P1, P4-tetraphosphate which appears to be involved in DNA replication and the control of cell proliferation. This review is a synthesis of recent results on the structure, genetics, cell biology, physiology, role in neoplasia, and role in autoimmune myositis of the higher eukaryotic aminoacyl-tRNA synthetases.

Original languageEnglish (US)
Pages (from-to)107-120
Number of pages14
JournalMolecular and Cellular Biochemistry
Volume71
Issue number2
DOIs
StatePublished - Aug 1986
Externally publishedYes

Keywords

  • aging
  • amino acid transport
  • aminoacyl-tRNA synthetase
  • diadenosine tetraphosphate
  • hormones
  • myositis
  • neoplasia
  • ontogenesis
  • protein synthesis
  • starvation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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