TY - JOUR
T1 - Higher circulating levels of uric acid are prospectively associated with better muscle function in older persons
AU - Macchi, Claudio
AU - Molino-Lova, Raffaele
AU - Polcaro, Paola
AU - Guarducci, Lorenzo
AU - Lauretani, Fulvio
AU - Cecchi, Francesca
AU - Bandinelli, Stefania
AU - Guralnik, Jack M.
AU - Ferrucci, Luigi
PY - 2008/9
Y1 - 2008/9
N2 - Background: Previous studies have shown that oxidative protein damage is independently associated with low grip strength and that dietary intake and circulating levels of antioxidant vitamins are positive predictors of muscle strength among older persons. Since uric acid (UA), has strong antioxidant properties, we tested the hypothesis that UA levels is cross-sectionaly associated with muscle strength and protective against the decline of strength over the aging process. Subjects and methods: 789 InCHIANTI Study participants underwent baseline serum UA, handgrip and knee extension torque measurements. Of these, 497 participants (226 men and 271 women, mean age 76.0 ± 5.4 years) also had follow-up strength measures. Lifestyle, comorbidities, nutritional profile, inflammatory markers and other laboratory measures were considered as potential confounders. Results: Follow-up strength measures significantly increased across baseline UA tertiles. After adjusting for potential confounders and analogous baseline strength measures, higher baseline UA levels still remained significantly associated with higher follow-up strength measures. Conclusions: Our findings suggest that higher levels of UA might represent a protective reaction aimed at counteracting the excessive production of free radicals that cause muscle protein damage and eventually contribute to the decline of muscle mass and strength.
AB - Background: Previous studies have shown that oxidative protein damage is independently associated with low grip strength and that dietary intake and circulating levels of antioxidant vitamins are positive predictors of muscle strength among older persons. Since uric acid (UA), has strong antioxidant properties, we tested the hypothesis that UA levels is cross-sectionaly associated with muscle strength and protective against the decline of strength over the aging process. Subjects and methods: 789 InCHIANTI Study participants underwent baseline serum UA, handgrip and knee extension torque measurements. Of these, 497 participants (226 men and 271 women, mean age 76.0 ± 5.4 years) also had follow-up strength measures. Lifestyle, comorbidities, nutritional profile, inflammatory markers and other laboratory measures were considered as potential confounders. Results: Follow-up strength measures significantly increased across baseline UA tertiles. After adjusting for potential confounders and analogous baseline strength measures, higher baseline UA levels still remained significantly associated with higher follow-up strength measures. Conclusions: Our findings suggest that higher levels of UA might represent a protective reaction aimed at counteracting the excessive production of free radicals that cause muscle protein damage and eventually contribute to the decline of muscle mass and strength.
KW - Antioxidants
KW - Elderly
KW - Muscle strength
KW - Sarcopenia
KW - Uric acid
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UR - http://www.scopus.com/inward/citedby.url?scp=46649087744&partnerID=8YFLogxK
U2 - 10.1016/j.mad.2008.04.008
DO - 10.1016/j.mad.2008.04.008
M3 - Article
C2 - 18534661
AN - SCOPUS:46649087744
SN - 0047-6374
VL - 129
SP - 522
EP - 527
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 9
ER -