Higher body mass index is associated with more adverse changes in calf muscle characteristics in peripheral arterial disease

Zankhana Raval, Kiang Liu, Lu Tian, Luigi Ferrucci, Jack M. Guralnik, Yihua Liao, Michael H. Criqui, Mary M. McDermott

Research output: Contribution to journalArticle

Abstract

Objective: This study investigated whether higher body mass index (BMI) is associated with more adverse lower extremity muscle characteristics at baseline and more adverse changes in muscle over time among participants with lower extremity peripheral arterial disease (PAD). Methods: This was a longitudinal, observational study of 425 men and women with PAD and 261 without PAD. Computed tomography was used to measure calf muscle characteristics at baseline and every 2 years. Knee extension isometric strength, power, and 6-minute walk distance were measured at baseline and annually. Baseline BMI (kg/m 2) categories were ideal (20-25), overweight (>25-30), and obese (>30). Analyses adjust for age, race, sex, ankle brachial index, comorbidities, and other covariates. Results: At baseline, higher BMI among participants with PAD was associated with greater calf muscle area (ideal BMI: 5181 mm 2; overweight: 5513 mm 2; obese: 5695 mm 2; P =.0009 for trend), higher calf muscle percentage of fat (6.38%, 10.28%, 17.44%, respectively, P

Original languageEnglish (US)
Pages (from-to)1015-1024
Number of pages10
JournalJournal of Vascular Surgery
Volume55
Issue number4
DOIs
StatePublished - Apr 2012
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Raval, Z., Liu, K., Tian, L., Ferrucci, L., Guralnik, J. M., Liao, Y., Criqui, M. H., & McDermott, M. M. (2012). Higher body mass index is associated with more adverse changes in calf muscle characteristics in peripheral arterial disease. Journal of Vascular Surgery, 55(4), 1015-1024. https://doi.org/10.1016/j.jvs.2011.10.105