Higher Body Mass Index Is Associated with Greater Proportions of Effector CD8+ T Cells Expressing CD57 in Women Living with HIV

the Women's Interagency HIV Study (WIHS)

Research output: Contribution to journalArticle

Abstract

Background: A low proportion of CD28- CD8+ T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing body mass index (BMI) changes in the proportion of CD57+ CD28- CD8+ T cells among HIV-infected individuals on antiretroviral therapy is unknown. Setting: In a US cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8+ T cell phenotypes: % CD28- CD57+ CD8+ T cells, % CD57+ of CD28- CD8+ T cells, and % CD28- of all CD8+ T cells. Methods: Multivariable linear regression analysis was used to estimate beta coefficients for each of 3 T-cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, and study site), and lifestyle (tobacco and alcohol use) factors. Results: Of 225 participants, the median age was 46 years and 50% were obese (BMI >30 m2/kg). Greater BMI and waist circumference were both associated with higher % CD28- CD57+ CD8+ T cells and % CD57+ of all CD28- CD8+ T cells in multivariable analysis, including adjustment for HIV viral load (all P < 0.05). The association between greater BMI and the overall proportion of CD28- CD8+ cells in fully adjusted models (0.078, 95% confidence interval: -0.053 to 0.209) was not significant. Conclusions: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28- CD8+ T cells and a greater proportion of CD57+ CD28- CD8+ T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.

Original languageEnglish (US)
Pages (from-to)e132-e141
JournalJournal of Acquired Immune Deficiency Syndromes
Volume75
Issue number5
DOIs
StatePublished - Aug 15 2017
Externally publishedYes

Fingerprint

Body Mass Index
HIV
T-Lymphocytes
Waist Circumference
Viral Load
Phenotype
Tobacco Use
HIV Infections
Life Style
Linear Models
Regression Analysis
Alcohols
Demography
Confidence Intervals
Mortality

Keywords

  • CD57
  • HIV
  • immune senescence
  • obesity
  • WIHS

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Higher Body Mass Index Is Associated with Greater Proportions of Effector CD8+ T Cells Expressing CD57 in Women Living with HIV. / the Women's Interagency HIV Study (WIHS).

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 75, No. 5, 15.08.2017, p. e132-e141.

Research output: Contribution to journalArticle

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title = "Higher Body Mass Index Is Associated with Greater Proportions of Effector CD8+ T Cells Expressing CD57 in Women Living with HIV",
abstract = "Background: A low proportion of CD28- CD8+ T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing body mass index (BMI) changes in the proportion of CD57+ CD28- CD8+ T cells among HIV-infected individuals on antiretroviral therapy is unknown. Setting: In a US cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8+ T cell phenotypes: {\%} CD28- CD57+ CD8+ T cells, {\%} CD57+ of CD28- CD8+ T cells, and {\%} CD28- of all CD8+ T cells. Methods: Multivariable linear regression analysis was used to estimate beta coefficients for each of 3 T-cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, and study site), and lifestyle (tobacco and alcohol use) factors. Results: Of 225 participants, the median age was 46 years and 50{\%} were obese (BMI >30 m2/kg). Greater BMI and waist circumference were both associated with higher {\%} CD28- CD57+ CD8+ T cells and {\%} CD57+ of all CD28- CD8+ T cells in multivariable analysis, including adjustment for HIV viral load (all P < 0.05). The association between greater BMI and the overall proportion of CD28- CD8+ cells in fully adjusted models (0.078, 95{\%} confidence interval: -0.053 to 0.209) was not significant. Conclusions: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28- CD8+ T cells and a greater proportion of CD57+ CD28- CD8+ T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.",
keywords = "CD57, HIV, immune senescence, obesity, WIHS",
author = "{the Women's Interagency HIV Study (WIHS)} and Reid, {Michael J.A.} and Baxi, {Sanjiv M.} and Sheira, {Lila A.} and Landay, {Alan L.} and Frongillo, {Edward A.} and Adebola Adedimeji and Cohen, {Mardge H.} and Eryka Wentz and Gustafson, {Deborah R.} and Daniel Merenstein and Hunt, {Peter W.} and Tien, {Phyllis C.} and Weiser, {Sheri D.} and Kathryn Anastos and Howard Minkoff and Mary Young and Ruth Greenblatt and Bradley Aouizerat and Alexandra Levine and Gange, {Stephen J}",
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T1 - Higher Body Mass Index Is Associated with Greater Proportions of Effector CD8+ T Cells Expressing CD57 in Women Living with HIV

AU - the Women's Interagency HIV Study (WIHS)

AU - Reid, Michael J.A.

AU - Baxi, Sanjiv M.

AU - Sheira, Lila A.

AU - Landay, Alan L.

AU - Frongillo, Edward A.

AU - Adedimeji, Adebola

AU - Cohen, Mardge H.

AU - Wentz, Eryka

AU - Gustafson, Deborah R.

AU - Merenstein, Daniel

AU - Hunt, Peter W.

AU - Tien, Phyllis C.

AU - Weiser, Sheri D.

AU - Anastos, Kathryn

AU - Minkoff, Howard

AU - Young, Mary

AU - Greenblatt, Ruth

AU - Aouizerat, Bradley

AU - Levine, Alexandra

AU - Gange, Stephen J

PY - 2017/8/15

Y1 - 2017/8/15

N2 - Background: A low proportion of CD28- CD8+ T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing body mass index (BMI) changes in the proportion of CD57+ CD28- CD8+ T cells among HIV-infected individuals on antiretroviral therapy is unknown. Setting: In a US cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8+ T cell phenotypes: % CD28- CD57+ CD8+ T cells, % CD57+ of CD28- CD8+ T cells, and % CD28- of all CD8+ T cells. Methods: Multivariable linear regression analysis was used to estimate beta coefficients for each of 3 T-cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, and study site), and lifestyle (tobacco and alcohol use) factors. Results: Of 225 participants, the median age was 46 years and 50% were obese (BMI >30 m2/kg). Greater BMI and waist circumference were both associated with higher % CD28- CD57+ CD8+ T cells and % CD57+ of all CD28- CD8+ T cells in multivariable analysis, including adjustment for HIV viral load (all P < 0.05). The association between greater BMI and the overall proportion of CD28- CD8+ cells in fully adjusted models (0.078, 95% confidence interval: -0.053 to 0.209) was not significant. Conclusions: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28- CD8+ T cells and a greater proportion of CD57+ CD28- CD8+ T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.

AB - Background: A low proportion of CD28- CD8+ T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing body mass index (BMI) changes in the proportion of CD57+ CD28- CD8+ T cells among HIV-infected individuals on antiretroviral therapy is unknown. Setting: In a US cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8+ T cell phenotypes: % CD28- CD57+ CD8+ T cells, % CD57+ of CD28- CD8+ T cells, and % CD28- of all CD8+ T cells. Methods: Multivariable linear regression analysis was used to estimate beta coefficients for each of 3 T-cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, and study site), and lifestyle (tobacco and alcohol use) factors. Results: Of 225 participants, the median age was 46 years and 50% were obese (BMI >30 m2/kg). Greater BMI and waist circumference were both associated with higher % CD28- CD57+ CD8+ T cells and % CD57+ of all CD28- CD8+ T cells in multivariable analysis, including adjustment for HIV viral load (all P < 0.05). The association between greater BMI and the overall proportion of CD28- CD8+ cells in fully adjusted models (0.078, 95% confidence interval: -0.053 to 0.209) was not significant. Conclusions: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28- CD8+ T cells and a greater proportion of CD57+ CD28- CD8+ T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.

KW - CD57

KW - HIV

KW - immune senescence

KW - obesity

KW - WIHS

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JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

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