Abstract
Although prostate cancer (PCa) is hypothesized to differ in nature between younger versus older patients, the underlying molecular distinctions are poorly understood. We hypothesized that high-throughput transcriptomic analysis would elucidate biological differences in PCas arising in younger versus older men, and would nominate potential age-specific biomarkers and therapeutic targets.Methods:The high-density Affymetrix GeneChip platform, encompassing >1 million genomic loci, was utilized to assess gene expression in 1090 radical prostatectomy samples from patients with long-term follow-up. We identified genes associated with metastatic progression by 10 years post-treatment in younger (age
Original language | English (US) |
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Pages (from-to) | 229-236 |
Number of pages | 8 |
Journal | Prostate Cancer and Prostatic Diseases |
Volume | 18 |
Issue number | 3 |
DOIs | |
State | Published - Sep 14 2015 |
ASJC Scopus subject areas
- Oncology
- Urology
- Cancer Research