High-throughput technologies for studying potassium channels - Progresses and challenges

Jia Xu, Ying Chen, Min Li

Research output: Contribution to journalReview articlepeer-review


Of the more than 400 ion channel genes in the human genome, at least 170 are known to encode potassium channels. Structural studies have provided atomic resolution of some potassium channels. In drug development, potassium channels have been both targets to focus upon and targets to avoid. The unique combination of functional and clinical attributes places potassium channels in an important position regarding both basic medical research and pharmaceutical therapeutics. This article discusses three topics: the biology of potassium channels, methods of detection, and challenges for detection assays and data interpretation.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalDrug Discovery Today: TARGETS
Issue number1
StatePublished - Jan 2004
Externally publishedYes

ASJC Scopus subject areas

  • Drug Discovery


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