High throughput probing of mechacal properties of cells

A. Adamo, A. Sharei, L. Adamo, B. Lee, S. Mao, K. Jensen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In a wide variety of diseases, mechanical properties of sick cells have been shown to be significantly different from those of healthy cells. However, present methods for assessing mechanical properties of cells are either very precise and slow or fast and inaccurate. Here we present a microfluidic based approach that provides information on cell size and stiffness with significantly higher throughputs than present approaches. The system is based on measurements of cell travel time thought a constriction. We show that travel time depends on cell diameter and cell stiffness and propose a new approach to a high throughput analysis of cell mechanics.

Original languageEnglish (US)
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
PublisherChemical and Biological Microsystems Society
Pages810-812
Number of pages3
ISBN (Print)9781618395955
StatePublished - 2011
Externally publishedYes
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume2011-January

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Country/TerritoryUnited States
CitySeattle, WA
Period10/2/1110/6/11

Keywords

  • Mechanical properties of cells
  • Microfluidics

ASJC Scopus subject areas

  • Control and Systems Engineering

Fingerprint

Dive into the research topics of 'High throughput probing of mechacal properties of cells'. Together they form a unique fingerprint.

Cite this