High-throughput monodisperse alginate gel bead formation using microfluidic pseudo-check valve

Cyrus Weijie Beh, Dara Kraitchman, Hai Quan Mao, Tza Huei Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports a microfluidic-based, high throughput method for preparing sub-100 micron monodisperse alginate microbeads at rates of up to 1 kHz. The robustness of the bead-generation system allows further scaling up. Various imaging contrast agents have been incorporated into these microbeads, which can be coated with a range of polycations to limit contrast agent leaching. The synthesized beads have been shown to remain stable for up to two months without aggregation. Cells can be co-encapsulated with the contrast agents, allowing imaging-assisted delivery of therapeutic cells.

Original languageEnglish (US)
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages425-427
Number of pages3
StatePublished - Dec 1 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume1

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/3/1010/7/10

Keywords

  • Alginate
  • Cell encapsulation
  • Magnetic resonance imaging
  • X-ray computed tomography

ASJC Scopus subject areas

  • Control and Systems Engineering

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