High speed optical imaging of the initiation and termination of self-sustaining cardiac spiral waves

Matthew G. Fishler, Ravi Ranjan, Nitish V. Thakor

Research output: Contribution to journalConference articlepeer-review

Abstract

The initiation, maintenance, and termination of 2-D spiral rotor in canine cardiac tissue are studied by staining a thin slice of epicardial tissue with the potentiometric dye di-4-ANEPPS and recording the resultant fluorescent signals with a 96-channel photodiode (PD) array at 500 frames/s. It was found that, at room temperature, the rotors revolved around a partially-depolarized central hub at approximately 3 Hz. Action potentials recorded at individual PDs distal from the hub revealed that the tissue fully repolarized before being reexcited by the return of the rotor's wavefront. Besides, these rotors could be terminated with a field stimulus greater than approx.10 V/cm, with refractory period extensions.

Original languageEnglish (US)
Pages (from-to)9-10
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume16
Issue numberpt 1
StatePublished - Dec 1 1994
EventProceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 (of 2) - Baltimore, MD, USA
Duration: Nov 3 1994Nov 6 1994

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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