High-Sensitivity Troponin as a Biomarker in Heart Rhythm Disease

Cian P. McCarthy, Omair Yousuf, Alvaro Alonso, Elizabeth Selvin, Hugh Calkins, John W. McEvoy

Research output: Contribution to journalReview article

Abstract

Biomarkers are important prognostic tools in various cardiovascular conditions, including coronary artery disease and heart failure. Although their utility in cardiac electrophysiology (EP) is less established, biomarkers may guide EP clinical practice by identifying patients at risk for developing arrhythmias and their complications, in addition to augmenting therapeutic decisions by targeting appropriate pharmacologic and interventional therapies to patients who may benefit most. In this review, we focus on the prognostic role of high-sensitivity cardiac troponin (hs-cTn) assays—which detect subclinical cardiac myocyte damage—in cardiac arrhythmias and their sequelae. We review the current literature on hs-cTn and its impact on various arrhythmia disease states and also provide suggestions for future research in this field. In conclusion, although the utility of hs-cTn assays remains at an investigational stage in cardiac EP, studies to date have suggested value as a prognostic biomarker in atrial fibrillation and as a screening marker for patients at high risk of sudden cardiac death (both in the general population and among those with hypertrophic cardiomyopathy).

Original languageEnglish (US)
Pages (from-to)1407-1413
Number of pages7
JournalAmerican Journal of Cardiology
Volume119
Issue number9
DOIs
StatePublished - May 1 2017

Fingerprint

Troponin
Cardiac Electrophysiology
Cardiac Arrhythmias
Heart Diseases
Biomarkers
Electrophysiology
Hypertrophic Cardiomyopathy
Sudden Cardiac Death
Cardiac Myocytes
Atrial Fibrillation
Coronary Artery Disease
Heart Failure
Therapeutics
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

High-Sensitivity Troponin as a Biomarker in Heart Rhythm Disease. / McCarthy, Cian P.; Yousuf, Omair; Alonso, Alvaro; Selvin, Elizabeth; Calkins, Hugh; McEvoy, John W.

In: American Journal of Cardiology, Vol. 119, No. 9, 01.05.2017, p. 1407-1413.

Research output: Contribution to journalReview article

McCarthy, Cian P. ; Yousuf, Omair ; Alonso, Alvaro ; Selvin, Elizabeth ; Calkins, Hugh ; McEvoy, John W. / High-Sensitivity Troponin as a Biomarker in Heart Rhythm Disease. In: American Journal of Cardiology. 2017 ; Vol. 119, No. 9. pp. 1407-1413.
@article{43bfc5a7204540beb85ce295faa79d30,
title = "High-Sensitivity Troponin as a Biomarker in Heart Rhythm Disease",
abstract = "Biomarkers are important prognostic tools in various cardiovascular conditions, including coronary artery disease and heart failure. Although their utility in cardiac electrophysiology (EP) is less established, biomarkers may guide EP clinical practice by identifying patients at risk for developing arrhythmias and their complications, in addition to augmenting therapeutic decisions by targeting appropriate pharmacologic and interventional therapies to patients who may benefit most. In this review, we focus on the prognostic role of high-sensitivity cardiac troponin (hs-cTn) assays—which detect subclinical cardiac myocyte damage—in cardiac arrhythmias and their sequelae. We review the current literature on hs-cTn and its impact on various arrhythmia disease states and also provide suggestions for future research in this field. In conclusion, although the utility of hs-cTn assays remains at an investigational stage in cardiac EP, studies to date have suggested value as a prognostic biomarker in atrial fibrillation and as a screening marker for patients at high risk of sudden cardiac death (both in the general population and among those with hypertrophic cardiomyopathy).",
author = "McCarthy, {Cian P.} and Omair Yousuf and Alvaro Alonso and Elizabeth Selvin and Hugh Calkins and McEvoy, {John W.}",
year = "2017",
month = "5",
day = "1",
doi = "10.1016/j.amjcard.2017.01.032",
language = "English (US)",
volume = "119",
pages = "1407--1413",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - High-Sensitivity Troponin as a Biomarker in Heart Rhythm Disease

AU - McCarthy, Cian P.

AU - Yousuf, Omair

AU - Alonso, Alvaro

AU - Selvin, Elizabeth

AU - Calkins, Hugh

AU - McEvoy, John W.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Biomarkers are important prognostic tools in various cardiovascular conditions, including coronary artery disease and heart failure. Although their utility in cardiac electrophysiology (EP) is less established, biomarkers may guide EP clinical practice by identifying patients at risk for developing arrhythmias and their complications, in addition to augmenting therapeutic decisions by targeting appropriate pharmacologic and interventional therapies to patients who may benefit most. In this review, we focus on the prognostic role of high-sensitivity cardiac troponin (hs-cTn) assays—which detect subclinical cardiac myocyte damage—in cardiac arrhythmias and their sequelae. We review the current literature on hs-cTn and its impact on various arrhythmia disease states and also provide suggestions for future research in this field. In conclusion, although the utility of hs-cTn assays remains at an investigational stage in cardiac EP, studies to date have suggested value as a prognostic biomarker in atrial fibrillation and as a screening marker for patients at high risk of sudden cardiac death (both in the general population and among those with hypertrophic cardiomyopathy).

AB - Biomarkers are important prognostic tools in various cardiovascular conditions, including coronary artery disease and heart failure. Although their utility in cardiac electrophysiology (EP) is less established, biomarkers may guide EP clinical practice by identifying patients at risk for developing arrhythmias and their complications, in addition to augmenting therapeutic decisions by targeting appropriate pharmacologic and interventional therapies to patients who may benefit most. In this review, we focus on the prognostic role of high-sensitivity cardiac troponin (hs-cTn) assays—which detect subclinical cardiac myocyte damage—in cardiac arrhythmias and their sequelae. We review the current literature on hs-cTn and its impact on various arrhythmia disease states and also provide suggestions for future research in this field. In conclusion, although the utility of hs-cTn assays remains at an investigational stage in cardiac EP, studies to date have suggested value as a prognostic biomarker in atrial fibrillation and as a screening marker for patients at high risk of sudden cardiac death (both in the general population and among those with hypertrophic cardiomyopathy).

UR - http://www.scopus.com/inward/record.url?scp=85014016843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014016843&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2017.01.032

DO - 10.1016/j.amjcard.2017.01.032

M3 - Review article

VL - 119

SP - 1407

EP - 1413

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 9

ER -