High-sensitivity nanosensors for biomarker detection

Magdalena Swierczewska, Gang Liu, Seulki Lee, Xiaoyuan Chen

Research output: Contribution to journalReview articlepeer-review

Abstract

High sensitivity nanosensors utilize optical, mechanical, electrical, and magnetic relaxation properties to push detection limits of biomarkers below previously possible concentrations. The unique properties of nanomaterials and nanotechnology are exploited to design biomarker diagnostics. High-sensitivity recognition is achieved by signal and target amplification along with thorough pre-processing of samples. In this tutorial review, we introduce the type of detection signals read by nanosensors to detect extremely small concentrations of biomarkers and provide distinctive examples of high-sensitivity sensors. The use of such high-sensitivity nanosensors can offer earlier detection of disease than currently available to patients and create significant improvements in clinical outcomes.

Original languageEnglish (US)
Pages (from-to)2641-2655
Number of pages15
JournalChemical Society Reviews
Volume41
Issue number7
DOIs
StatePublished - Apr 7 2012
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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