High-sensitivity C-reactive protein as an independent predictor of progressive myocardial functional deterioration: The multiethnic study of atherosclerosis

Eui Young Choi, Raymond T. Yan, Veronica R S Fernandes, Anders Opdahl, Antoinette S. Gomes, Andre L C Almeida, Colin O. Wu, Kiang Liu, Jeffrey J. Carr, Robyn L. McClelland, David A. Bluemke, Joao Lima

Research output: Contribution to journalArticle

Abstract

Background: Systemic inflammation has been linked to the development of heart failure in population studies including Multi-Ethnic Study of Atherosclerosis (MESA), but little evidence exists regarding potential mechanism of this relationship. In this study, we used longitudinal magnetic resonance imaging follow-up analysis to examine whether C-reactive protein (CRP) levels relate to progressive myocardial functional deterioration as a potential mechanism of incident heart failure. Methods: Regional myocardial functional data from MESA participants who had baseline CRP measurement and also underwent tagged cardiac magnetic resonance imaging both at baseline and at 5-year follow-up were analyzed. Left ventricular midwall and midslice peak circumferential strain (Ecc), of which a more negative value denotes stronger regional myocardial function, was measured. Circumferential strain change was calculated as the difference between baseline and follow-up Ecc. Results: During the follow-up period, participants (n = 785) with elevated CRP experienced a decrease in strain, independent of age, gender, and ethnicity (B = 0.081, ΔEcc change per 1 mg/L CRP change, 95% CI 0.036-0.126, P

Original languageEnglish (US)
Pages (from-to)251-258
Number of pages8
JournalAmerican Heart Journal
Volume164
Issue number2
DOIs
StatePublished - Aug 2012

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C-Reactive Protein
Atherosclerosis
Heart Failure
Magnetic Resonance Imaging
Inflammation
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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High-sensitivity C-reactive protein as an independent predictor of progressive myocardial functional deterioration : The multiethnic study of atherosclerosis. / Choi, Eui Young; Yan, Raymond T.; Fernandes, Veronica R S; Opdahl, Anders; Gomes, Antoinette S.; Almeida, Andre L C; Wu, Colin O.; Liu, Kiang; Carr, Jeffrey J.; McClelland, Robyn L.; Bluemke, David A.; Lima, Joao.

In: American Heart Journal, Vol. 164, No. 2, 08.2012, p. 251-258.

Research output: Contribution to journalArticle

Choi, EY, Yan, RT, Fernandes, VRS, Opdahl, A, Gomes, AS, Almeida, ALC, Wu, CO, Liu, K, Carr, JJ, McClelland, RL, Bluemke, DA & Lima, J 2012, 'High-sensitivity C-reactive protein as an independent predictor of progressive myocardial functional deterioration: The multiethnic study of atherosclerosis', American Heart Journal, vol. 164, no. 2, pp. 251-258. https://doi.org/10.1016/j.ahj.2012.05.010
Choi, Eui Young ; Yan, Raymond T. ; Fernandes, Veronica R S ; Opdahl, Anders ; Gomes, Antoinette S. ; Almeida, Andre L C ; Wu, Colin O. ; Liu, Kiang ; Carr, Jeffrey J. ; McClelland, Robyn L. ; Bluemke, David A. ; Lima, Joao. / High-sensitivity C-reactive protein as an independent predictor of progressive myocardial functional deterioration : The multiethnic study of atherosclerosis. In: American Heart Journal. 2012 ; Vol. 164, No. 2. pp. 251-258.
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