High-Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change

Yashashwi Pokharel, Farah Mouhanna, Andrea L.C. Schneider, Andreea M. Rawlings, David S. Knopman, Vijay Nambi, Salim S. Virani, Ron C. Hoogeveen, Alvaro Alonso, Gerardo Heiss, Josef Coresh, Thomas Mosley, Rebecca F Gottesman, Elizabeth Selvin, Christie Ballantyne, Melinda C. Power

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Cardiac troponin T, measured using a high-sensitive assay (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are associated with increased stroke risk and perhaps with cognitive decline. However, few well-designed prospective studies with extended follow-up have been conducted. We aimed to estimate the association of hs-cTnT and NT-proBNP with 15-year cognitive change in the Atherosclerosis Risk in Communities (ARIC) study. DESIGN: Prospective cohort study. SETTING: Four US communities. PARTICIPANTS: A total of 9114 and 9108 participants from the Atherosclerosis Risk in Communities study for analyses of hs-cTnT and NT-proBNP, respectively. MEASUREMENTS: We examined association of hs-cTnT and NT-proBNP with 15-year change (1996-1998 to 2011-2013) in three cognitive tests of executive function (Digit Symbol Substitution Test), verbal learning memory (Delayed Word Recall Test), and semantic fluency (Word Fluency Test), and an overall score combining the three tests using multivariable linear mixed effect models. We conducted several sensitivity analyses including multiple imputations to address bias due to missing data and attrition, and we compared associations within groups combining hs-cTnT and NT-proBNP into a three-level categorical variable. RESULTS: At baseline (1996-1998), mean age was 63.4 (standard deviation [SD] = 5.7) years; 56.4% were women, and 17.5% were black. The hs-cTnT at baseline was not associated with cognitive change in any measure. Some evidence indicated accelerated decline in verbal learning and memory when comparing those in the highest with the lowest NT-proBNP quintiles; however, this association was not replicated when considering clinically relevant cutoffs or deciles of exposure in survivors. Sensitivity analyses were consistent with our primary analyses. There was little evidence to support effect modification by any considered factors. People with highest levels of both biomarkers had excessive decline in global z scores vs people with lowest levels (−.34; 95% confidence interval = −.63 to −.04). CONCLUSION: Markers of myocardial injury and stretch were not associated with cognitive decline following 15 years among survivors, but when combined together they were suggestive in post hoc analysis. Whether this represents targets of intervention should be examined in the future.

Original languageEnglish (US)
JournalJournal of the American Geriatrics Society
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Natriuretic Peptides
Troponin T
Brain Natriuretic Peptide
Verbal Learning
Survivors
Atherosclerosis
Repression (Psychology)
Prospective Studies
Executive Function
Semantics
Cohort Studies
Biomarkers
Stroke
Confidence Intervals
Wounds and Injuries

Keywords

  • cognitive change
  • dementia
  • high-sensitivity troponin
  • N-terminal pro-B-type natriuretic peptide

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Pokharel, Y., Mouhanna, F., Schneider, A. L. C., Rawlings, A. M., Knopman, D. S., Nambi, V., ... Power, M. C. (Accepted/In press). High-Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.16092

High-Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change. / Pokharel, Yashashwi; Mouhanna, Farah; Schneider, Andrea L.C.; Rawlings, Andreea M.; Knopman, David S.; Nambi, Vijay; Virani, Salim S.; Hoogeveen, Ron C.; Alonso, Alvaro; Heiss, Gerardo; Coresh, Josef; Mosley, Thomas; Gottesman, Rebecca F; Selvin, Elizabeth; Ballantyne, Christie; Power, Melinda C.

In: Journal of the American Geriatrics Society, 01.01.2019.

Research output: Contribution to journalArticle

Pokharel, Y, Mouhanna, F, Schneider, ALC, Rawlings, AM, Knopman, DS, Nambi, V, Virani, SS, Hoogeveen, RC, Alonso, A, Heiss, G, Coresh, J, Mosley, T, Gottesman, RF, Selvin, E, Ballantyne, C & Power, MC 2019, 'High-Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change', Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.16092
Pokharel, Yashashwi ; Mouhanna, Farah ; Schneider, Andrea L.C. ; Rawlings, Andreea M. ; Knopman, David S. ; Nambi, Vijay ; Virani, Salim S. ; Hoogeveen, Ron C. ; Alonso, Alvaro ; Heiss, Gerardo ; Coresh, Josef ; Mosley, Thomas ; Gottesman, Rebecca F ; Selvin, Elizabeth ; Ballantyne, Christie ; Power, Melinda C. / High-Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change. In: Journal of the American Geriatrics Society. 2019.
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T1 - High-Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change

AU - Pokharel, Yashashwi

AU - Mouhanna, Farah

AU - Schneider, Andrea L.C.

AU - Rawlings, Andreea M.

AU - Knopman, David S.

AU - Nambi, Vijay

AU - Virani, Salim S.

AU - Hoogeveen, Ron C.

AU - Alonso, Alvaro

AU - Heiss, Gerardo

AU - Coresh, Josef

AU - Mosley, Thomas

AU - Gottesman, Rebecca F

AU - Selvin, Elizabeth

AU - Ballantyne, Christie

AU - Power, Melinda C.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - OBJECTIVES: Cardiac troponin T, measured using a high-sensitive assay (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are associated with increased stroke risk and perhaps with cognitive decline. However, few well-designed prospective studies with extended follow-up have been conducted. We aimed to estimate the association of hs-cTnT and NT-proBNP with 15-year cognitive change in the Atherosclerosis Risk in Communities (ARIC) study. DESIGN: Prospective cohort study. SETTING: Four US communities. PARTICIPANTS: A total of 9114 and 9108 participants from the Atherosclerosis Risk in Communities study for analyses of hs-cTnT and NT-proBNP, respectively. MEASUREMENTS: We examined association of hs-cTnT and NT-proBNP with 15-year change (1996-1998 to 2011-2013) in three cognitive tests of executive function (Digit Symbol Substitution Test), verbal learning memory (Delayed Word Recall Test), and semantic fluency (Word Fluency Test), and an overall score combining the three tests using multivariable linear mixed effect models. We conducted several sensitivity analyses including multiple imputations to address bias due to missing data and attrition, and we compared associations within groups combining hs-cTnT and NT-proBNP into a three-level categorical variable. RESULTS: At baseline (1996-1998), mean age was 63.4 (standard deviation [SD] = 5.7) years; 56.4% were women, and 17.5% were black. The hs-cTnT at baseline was not associated with cognitive change in any measure. Some evidence indicated accelerated decline in verbal learning and memory when comparing those in the highest with the lowest NT-proBNP quintiles; however, this association was not replicated when considering clinically relevant cutoffs or deciles of exposure in survivors. Sensitivity analyses were consistent with our primary analyses. There was little evidence to support effect modification by any considered factors. People with highest levels of both biomarkers had excessive decline in global z scores vs people with lowest levels (−.34; 95% confidence interval = −.63 to −.04). CONCLUSION: Markers of myocardial injury and stretch were not associated with cognitive decline following 15 years among survivors, but when combined together they were suggestive in post hoc analysis. Whether this represents targets of intervention should be examined in the future.

AB - OBJECTIVES: Cardiac troponin T, measured using a high-sensitive assay (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are associated with increased stroke risk and perhaps with cognitive decline. However, few well-designed prospective studies with extended follow-up have been conducted. We aimed to estimate the association of hs-cTnT and NT-proBNP with 15-year cognitive change in the Atherosclerosis Risk in Communities (ARIC) study. DESIGN: Prospective cohort study. SETTING: Four US communities. PARTICIPANTS: A total of 9114 and 9108 participants from the Atherosclerosis Risk in Communities study for analyses of hs-cTnT and NT-proBNP, respectively. MEASUREMENTS: We examined association of hs-cTnT and NT-proBNP with 15-year change (1996-1998 to 2011-2013) in three cognitive tests of executive function (Digit Symbol Substitution Test), verbal learning memory (Delayed Word Recall Test), and semantic fluency (Word Fluency Test), and an overall score combining the three tests using multivariable linear mixed effect models. We conducted several sensitivity analyses including multiple imputations to address bias due to missing data and attrition, and we compared associations within groups combining hs-cTnT and NT-proBNP into a three-level categorical variable. RESULTS: At baseline (1996-1998), mean age was 63.4 (standard deviation [SD] = 5.7) years; 56.4% were women, and 17.5% were black. The hs-cTnT at baseline was not associated with cognitive change in any measure. Some evidence indicated accelerated decline in verbal learning and memory when comparing those in the highest with the lowest NT-proBNP quintiles; however, this association was not replicated when considering clinically relevant cutoffs or deciles of exposure in survivors. Sensitivity analyses were consistent with our primary analyses. There was little evidence to support effect modification by any considered factors. People with highest levels of both biomarkers had excessive decline in global z scores vs people with lowest levels (−.34; 95% confidence interval = −.63 to −.04). CONCLUSION: Markers of myocardial injury and stretch were not associated with cognitive decline following 15 years among survivors, but when combined together they were suggestive in post hoc analysis. Whether this represents targets of intervention should be examined in the future.

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