High-risk human papillomavirus in nasopharyngeal carcinoma

Aatur D. Singhi, Joseph Califano, William H. Westra

Research output: Contribution to journalArticle

Abstract

Background Human papillomavirus (HPV), a cause of oropharyngeal carcinoma, has also been implicated as an etiologic agent in nasopharyngeal carcinomas. Methods We performed p16 immunohistochemistry and in situ hybridization for Epstein-Barr virus (EBV) and HPV on 45 carcinomas of the nasopharynx. Results Thirty-four (76%) carcinomas were EBV-positive/HPV-negative, 7 (16%) were EBV-negative/HPV-negative, and 4 (9%) were EBV-negative/HPV-positive. HPV was more likely to be detected in carcinomas from white patients than non-white patients (16% vs 0%; p =.03). Of the 3 patients with HPV-positive carcinomas and available staging information, all were found to have extension into the oropharynx. All HPV-positive carcinomas were p16 positive, but none of the HPV-negative carcinomas were p16 positive (p

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalHead and Neck
Volume34
Issue number2
DOIs
StatePublished - Feb 2012

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Carcinoma
Human Herpesvirus 4
Gammapapillomavirus
Oropharynx
Nasopharynx
Nasopharyngeal carcinoma
In Situ Hybridization
Immunohistochemistry

Keywords

  • Epstein-Barr virus
  • head and neck squamous cell carcinoma
  • lymphoepithelioma
  • oropharyngeal carcinoma
  • p16 immunohistochemistry

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Singhi, A. D., Califano, J., & Westra, W. H. (2012). High-risk human papillomavirus in nasopharyngeal carcinoma. Head and Neck, 34(2), 213-218. https://doi.org/10.1002/hed.21714

High-risk human papillomavirus in nasopharyngeal carcinoma. / Singhi, Aatur D.; Califano, Joseph; Westra, William H.

In: Head and Neck, Vol. 34, No. 2, 02.2012, p. 213-218.

Research output: Contribution to journalArticle

Singhi, AD, Califano, J & Westra, WH 2012, 'High-risk human papillomavirus in nasopharyngeal carcinoma', Head and Neck, vol. 34, no. 2, pp. 213-218. https://doi.org/10.1002/hed.21714
Singhi, Aatur D. ; Califano, Joseph ; Westra, William H. / High-risk human papillomavirus in nasopharyngeal carcinoma. In: Head and Neck. 2012 ; Vol. 34, No. 2. pp. 213-218.
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