High-Risk, High-Reward Genetics in ASD

Christina A. Castellani; Dan E. Arking

doi:10.1016/j.neuron.2020.01.007

High-Risk, High-Reward Genetics in ASD

Christina A. Castellani, Dan E. Arking

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

In a recent issue of Cell, Satterstrom et al. leverage de novo high-impact variants to identify 102 genes associated with autism spectrum disorder (ASD). Most of these genes have roles in regulation of gene expression or neuronal communication, implicating both developmental and functional changes in ASD.

Original language	English (US)
Pages (from-to)	407-410
Number of pages	4
Journal	Neuron
Volume	105
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2020.01.007
State	Published - Feb 5 2020

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2020.01.007

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title = "High-Risk, High-Reward Genetics in ASD",

abstract = "In a recent issue of Cell, Satterstrom et al. leverage de novo high-impact variants to identify 102 genes associated with autism spectrum disorder (ASD). Most of these genes have roles in regulation of gene expression or neuronal communication, implicating both developmental and functional changes in ASD.",

author = "Castellani, {Christina A.} and Arking, {Dan E.}",

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AU - Arking, Dan E.

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AB - In a recent issue of Cell, Satterstrom et al. leverage de novo high-impact variants to identify 102 genes associated with autism spectrum disorder (ASD). Most of these genes have roles in regulation of gene expression or neuronal communication, implicating both developmental and functional changes in ASD.

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High-Risk, High-Reward Genetics in ASD

Abstract

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