High-resolution scintimammography: A pilot study

Rachel F. Brem, Joelle M. Schoonjans, Douglas A. Kieper, Stan Majewski, Steven Goodman, Cahid Civelek

Research output: Contribution to journalArticle

Abstract

This study evaluated a novel high-resolution breast-specific gamma camera (HRBGC) for the detection of suggestive breast lesions. Methods: Fifty patients (with 58 breast lesions) for whom a scintimammogram was clinically indicated were prospectively evaluated with a general-purpose gamma camera and a novel HRBGC prototype. The results of conventional and high-resolution nuclear studies were prospectively classified as negative (normal or benign) or positive (suggestive or malignant) by 2 radiologists who were unaware of the mammographic and histologic results. All of the included lesions were confirmed by pathology. Results: There were 30 benign and 28 malignant lesions. The sensitivity for detection of breast cancer was 64.3% (18/28) with the conventional camera and 78.6% (22/28) with the HRBGC. The specificity with both systems was 93.3% (28/30). For the 18 nonpalpable lesions, sensitivity was 55.5% (10/18) and 72.2% (13/18) with the general-purpose camera and the HRBGC, respectively. For lesions ≤ 1 cm, 7 of 15 were detected with the general-purpose camera and 10 of 15 with the HRBGC. Four lesions (median size, 8.5 mm) were detected only with the HRBGC and were missed by the conventional camera. Conclusion: Evaluation of indeterminate breast lesions with an HRBGC results in improved sensitivity for the detection of cancer, with greater improvement shown for nonpalpable and ≤1-cm lesions.

Original languageEnglish (US)
Pages (from-to)909-915
Number of pages7
JournalJournal of Nuclear Medicine
Volume43
Issue number7
StatePublished - Jul 20 2002

Keywords

  • Breast neoplasm
  • High-resolution gamma camera
  • Scintimammography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Brem, R. F., Schoonjans, J. M., Kieper, D. A., Majewski, S., Goodman, S., & Civelek, C. (2002). High-resolution scintimammography: A pilot study. Journal of Nuclear Medicine, 43(7), 909-915.