TY - JOUR
T1 - High-resolution MRI vessel wall imaging in varicella zoster virus vasculopathy
AU - Cheng-Ching, Esteban
AU - Jones, Stephen
AU - Hui, Ferdinand K.
AU - Man, Shumei
AU - Gilden, Don
AU - Bhimraj, Adarsh
AU - Uchino, Ken
N1 - Funding Information:
This work was supported in part by Public Health Service grants AG032958 and AG006127 from the National Institutes of Health . The authors thank Marina Hoffman for editorial assistance and Cathy Allen for the word processing and formatting of the manuscript.
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/4/15
Y1 - 2015/4/15
N2 - Contrast-enhanced vessel wall imaging high-resolution MRI (HRMR) has revealed vessel wall thickening and enhancement in multiple intracranial vasculopathies, including varicella zoster virus (VZV) vasculopathy. We retrospectively reviewed a database of patients with virologically-verified VZV vasculopathy, who underwent initial and follow-up HRMR between April 2011 and May 2014. Six patients were identified. Baseline demographic and clinical characteristics were collected, including stroke risk factors, history of VZV-related disorders, neurological presentation, course and antiviral treatment. Initial HRMR in patients with VZV vasculopathy demonstrated various patterns of stenosis, vessel wall thickening and enhancement, predominantly in terminal internal carotid artery segments and the M1 segment of the middle cerebral arteries. Follow-up HRMR showed improvement of stenosis, with reduced vessel wall thickening and enhancement at multiple times after treatment. HRMR has the potential to assist in diagnosis and treatment of VZV vasculopathy.
AB - Contrast-enhanced vessel wall imaging high-resolution MRI (HRMR) has revealed vessel wall thickening and enhancement in multiple intracranial vasculopathies, including varicella zoster virus (VZV) vasculopathy. We retrospectively reviewed a database of patients with virologically-verified VZV vasculopathy, who underwent initial and follow-up HRMR between April 2011 and May 2014. Six patients were identified. Baseline demographic and clinical characteristics were collected, including stroke risk factors, history of VZV-related disorders, neurological presentation, course and antiviral treatment. Initial HRMR in patients with VZV vasculopathy demonstrated various patterns of stenosis, vessel wall thickening and enhancement, predominantly in terminal internal carotid artery segments and the M1 segment of the middle cerebral arteries. Follow-up HRMR showed improvement of stenosis, with reduced vessel wall thickening and enhancement at multiple times after treatment. HRMR has the potential to assist in diagnosis and treatment of VZV vasculopathy.
KW - Angiography
KW - High-resolution
KW - MRI
KW - Treatment
KW - Varicella zoster virus
KW - Vasculopathy
UR - http://www.scopus.com/inward/record.url?scp=84926418121&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926418121&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2015.02.017
DO - 10.1016/j.jns.2015.02.017
M3 - Article
C2 - 25732801
AN - SCOPUS:84926418121
SN - 0022-510X
VL - 351
SP - 168
EP - 173
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -