High-resolution mapping of d16led-1, gart, gas-4, cbr, pcp-4, and erg on distal mouse chromosome 16

Anne E. Mjaatvedt, Michael P. Citron, Roger H. Reeves

Research output: Contribution to journalArticle

Abstract

More than 500 backcross progeny from four intersubspecific backcrosses were typed for six markers on distal mouse chromosome 16. Five of these represented genes that mapped within the Sod-1 to Ets-2 interval, which was shown previously to contain the weaver (wv) gene. The map order, including previously mapped reference markers, is (cen)-D16H21S16-D16Led-1-App-Sod-1-Gart-Gas-4-Cbr-wv-Pcp-4-Erg-Ets-2. This gene order recapitulates the order of the genes on human chromosome 21 where known. Two of these markers further define the region containing the weaver gene to a 3.9-cM segment between Cbr and Pcp-4. In addition, Pcp-4 was localized to human chromosome 21 by the presence of a human-specific restriction fragment in WAV-17, a mouse-human somatic cell hybrid with human chromosome 21 as the only human contribution.

Original languageEnglish (US)
Pages (from-to)382-386
Number of pages5
JournalGenomics
Volume17
Issue number2
DOIs
StatePublished - Aug 1993

ASJC Scopus subject areas

  • Genetics

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