High-resolution fluorodeoxyglucose positron emission tomography with compression ("positron emission mammography") is highly accurate in depicting primary breast cancer

Wendie A. Berg, Irving N. Weinberg, Deepa Narayanan, Mary E. Lobrano, Eric Ross, Laura Amodei, Lorraine Tafra, Lee P. Adler, Joseph Uddo, William Stein, Edward A. Levine

Research output: Contribution to journalArticle

Abstract

We sought to prospectively assess the diagnostic performance of a high-resolution positron emission tomography (PET) scanner using mild breast compression (positron emission mammography [PEM]). Data were collected on concomitant medical conditions to assess potential confounding factors. At four centers, 94 consecutive women with known breast cancer or suspicious breast lesions received 18F-fluorodeoxyglucose (FDG) intravenously, followed by PEM scans. Readers were provided clinical histories and x-ray mammograms (when available). After excluding inevaluable cases and two cases of lymphoma, PEM readings were correlated with histopathology for 92 lesions in 77 women: 77 index lesions (42 malignant), 3 ipsilateral lesions (3 malignant), and 12 contralateral lesions (3 malignant). Of 48 cancers, 16 (33%) were clinically evident; 11 (23%) were ductal carcinoma in situ (DCIS), and 37 (77%) were invasive (30 ductal, 4 lobular, and 3 mixed; median size 21 mm). PEM depicted 10 of 11 (91%) DCIS and 33 of 37 (89%) invasive cancers. PEM was positive in 1 of 2 T1a tumors, 4 of 6 T1b tumors, 7 of 7 T1c tumors, and 4 of 4 cases where tumor size was not available (e.g., no surgical follow-up). PEM sensitivity for detecting cancer was 90%, specificity 86%, positive predictive value (PPV) 88%, negative predictive value (NPV) 88%, accuracy 88%, and area under the receiver-operating characteristic curve (Az) 0.918. In three patients, cancer foci were identified only on PEM, significantly changing patient management. Excluding eight diabetic subjects and eight subjects whose lesions were characterized as clearly benign with conventional imaging, PEM sensitivity was 91%, specificity 93%, PPV 95%, NPV 88%, accuracy 92%, and A z 0.949 when interpreted with mammographic and clinical findings. FDG PEM has high diagnostic accuracy for breast lesions, including DCIS.

Original languageEnglish (US)
Pages (from-to)309-323
Number of pages15
JournalBreast Journal
Volume12
Issue number4
DOIs
StatePublished - Jul 2006
Externally publishedYes

Fingerprint

Mammography
Positron-Emission Tomography
Electrons
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Neoplasms
Breast
Fluorodeoxyglucose F18
ROC Curve
Reading
Lymphoma
X-Rays

Keywords

  • Breast cancer
  • Fluorodeoxyglucose
  • Positron emission mammography
  • Positron emission tomography

ASJC Scopus subject areas

  • Internal Medicine
  • Oncology

Cite this

High-resolution fluorodeoxyglucose positron emission tomography with compression ("positron emission mammography") is highly accurate in depicting primary breast cancer. / Berg, Wendie A.; Weinberg, Irving N.; Narayanan, Deepa; Lobrano, Mary E.; Ross, Eric; Amodei, Laura; Tafra, Lorraine; Adler, Lee P.; Uddo, Joseph; Stein, William; Levine, Edward A.

In: Breast Journal, Vol. 12, No. 4, 07.2006, p. 309-323.

Research output: Contribution to journalArticle

Berg, WA, Weinberg, IN, Narayanan, D, Lobrano, ME, Ross, E, Amodei, L, Tafra, L, Adler, LP, Uddo, J, Stein, W & Levine, EA 2006, 'High-resolution fluorodeoxyglucose positron emission tomography with compression ("positron emission mammography") is highly accurate in depicting primary breast cancer', Breast Journal, vol. 12, no. 4, pp. 309-323. https://doi.org/10.1111/j.1075-122X.2006.00269.x
Berg, Wendie A. ; Weinberg, Irving N. ; Narayanan, Deepa ; Lobrano, Mary E. ; Ross, Eric ; Amodei, Laura ; Tafra, Lorraine ; Adler, Lee P. ; Uddo, Joseph ; Stein, William ; Levine, Edward A. / High-resolution fluorodeoxyglucose positron emission tomography with compression ("positron emission mammography") is highly accurate in depicting primary breast cancer. In: Breast Journal. 2006 ; Vol. 12, No. 4. pp. 309-323.
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abstract = "We sought to prospectively assess the diagnostic performance of a high-resolution positron emission tomography (PET) scanner using mild breast compression (positron emission mammography [PEM]). Data were collected on concomitant medical conditions to assess potential confounding factors. At four centers, 94 consecutive women with known breast cancer or suspicious breast lesions received 18F-fluorodeoxyglucose (FDG) intravenously, followed by PEM scans. Readers were provided clinical histories and x-ray mammograms (when available). After excluding inevaluable cases and two cases of lymphoma, PEM readings were correlated with histopathology for 92 lesions in 77 women: 77 index lesions (42 malignant), 3 ipsilateral lesions (3 malignant), and 12 contralateral lesions (3 malignant). Of 48 cancers, 16 (33{\%}) were clinically evident; 11 (23{\%}) were ductal carcinoma in situ (DCIS), and 37 (77{\%}) were invasive (30 ductal, 4 lobular, and 3 mixed; median size 21 mm). PEM depicted 10 of 11 (91{\%}) DCIS and 33 of 37 (89{\%}) invasive cancers. PEM was positive in 1 of 2 T1a tumors, 4 of 6 T1b tumors, 7 of 7 T1c tumors, and 4 of 4 cases where tumor size was not available (e.g., no surgical follow-up). PEM sensitivity for detecting cancer was 90{\%}, specificity 86{\%}, positive predictive value (PPV) 88{\%}, negative predictive value (NPV) 88{\%}, accuracy 88{\%}, and area under the receiver-operating characteristic curve (Az) 0.918. In three patients, cancer foci were identified only on PEM, significantly changing patient management. Excluding eight diabetic subjects and eight subjects whose lesions were characterized as clearly benign with conventional imaging, PEM sensitivity was 91{\%}, specificity 93{\%}, PPV 95{\%}, NPV 88{\%}, accuracy 92{\%}, and A z 0.949 when interpreted with mammographic and clinical findings. FDG PEM has high diagnostic accuracy for breast lesions, including DCIS.",
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AU - Ross, Eric

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