High-resolution deletion mapping of chromosome arm I p in pancreatic cancer identifies a major consensus region at 1p35

Werner Hilgers, David J. Tang, Avrahom Y. Sugar, Manu C. Shekher, Ralph H. Hruban, Scott E. Kern

Research output: Contribution to journalArticle

Abstract

Chromosomal arm 1p has long been suspected, on the basis of loss of heterozygosity (LOH) and other data, to harbor a tumor suppressor gene important in pancreatic carcinomas and other tumors. We constructed a high- resolution map of LOH at 1 p in a panel of pancreatic adenocarcinomas. Using 44 markers, we identified LOH on 1p in 49% of 43 cancers. Breakpoints in 1p were identified in 15 of the carcinomas and could be used to ascertain consensus patterns. We found a major consensus region of LOH at 1p35 between loci D1S233 and D1S247. This region participates in the majority of LOH events on 1 p in pancreatic cancer. These data provide a roadmap for further regional mapping, homozygous deletion searches, comparison to LOH patterns seen in other tumor types, and prioritization of studies using candidate genes.

Original languageEnglish (US)
Pages (from-to)351-355
Number of pages5
JournalGenes Chromosomes and Cancer
Volume24
Issue number4
DOIs
StatePublished - Apr 1 1999

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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