Abstract
Centrilobular emphysema (CLE) is a disease defined pathologically. Assessment of the accuracy of high resolution computed tomography (CT) in the diagnosis of centrilobular emphysema has been hampered by a lack of pathologic correlation. We applied high resolution computed tomography to 20 postmortem lung specimens fixed by a method that allows for direct one-to-one pathologic-radiologic correlation. The degree of centrilobular emphysema was assessed radiologically on a visual grading system based on nonperipheral low-attenuation areas. The lungs were then sectioned along the plane of the CT image, and the degree of centrilobular emphysema was graded pathologically by scoring against a panel of standards. A significant correlation (r = 0.91, p < 0.005) was found between the pathologic grade and the in vitro CT score.
Original language | English (US) |
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Pages (from-to) | 935-940 |
Number of pages | 6 |
Journal | American Review of Respiratory Disease |
Volume | 136 |
Issue number | 4 |
DOIs | |
State | Published - 1987 |
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine