High resolution computed tomography of inflation-fixed lungs. Pathologic-radiologic correlation of centrilobular emphysema

R. H. Hruban, M. A. Meziane, E. A. Zerhouni, N. F. Khouri, E. K. Fishman, P. S. Wheeler, J. Stephen Dumler, G. M. Hutchins

Research output: Contribution to journalArticlepeer-review

Abstract

Centrilobular emphysema (CLE) is a disease defined pathologically. Assessment of the accuracy of high resolution computed tomography (CT) in the diagnosis of centrilobular emphysema has been hampered by a lack of pathologic correlation. We applied high resolution computed tomography to 20 postmortem lung specimens fixed by a method that allows for direct one-to-one pathologic-radiologic correlation. The degree of centrilobular emphysema was assessed radiologically on a visual grading system based on nonperipheral low-attenuation areas. The lungs were then sectioned along the plane of the CT image, and the degree of centrilobular emphysema was graded pathologically by scoring against a panel of standards. A significant correlation (r = 0.91, p < 0.005) was found between the pathologic grade and the in vitro CT score.

Original languageEnglish (US)
Pages (from-to)935-940
Number of pages6
JournalAmerican Review of Respiratory Disease
Volume136
Issue number4
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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