High resolution computed tomography of inflation-fixed lungs. Pathologic-radiologic correlation of centrilobular emphysema

R. H. Hruban, M. A. Meziane, E. A. Zerhouni, N. F. Khouri, E. K. Fishman, Paul S Wheeler, J. Stephen Dumler, G. M. Hutchins

Research output: Contribution to journalArticlepeer-review

Abstract

Centrilobular emphysema (CLE) is a disease defined pathologically. Assessment of the accuracy of high resolution computed tomography (CT) in the diagnosis of centrilobular emphysema has been hampered by a lack of pathologic correlation. We applied high resolution computed tomography to 20 postmortem lung specimens fixed by a method that allows for direct one-to-one pathologic-radiologic correlation. The degree of centrilobular emphysema was assessed radiologically on a visual grading system based on nonperipheral low-attenuation areas. The lungs were then sectioned along the plane of the CT image, and the degree of centrilobular emphysema was graded pathologically by scoring against a panel of standards. A significant correlation (r = 0.91, p < 0.005) was found between the pathologic grade and the in vitro CT score.

Original languageEnglish (US)
Pages (from-to)935-940
Number of pages6
JournalAmerican Review of Respiratory Disease
Volume136
Issue number4
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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