High resolution and high sensitivity detectors for functional molecular imaging with radionuclides: The role of scintillator pixel size, photodetector anode pitch, collimation technique, and of the readout

F. Garibaldi, R. Accorsi, M. N. Cinti, E. Cisbani, S. Colilli, F. Cusanno, R. Fratoni, F. Giuliani, M. Gricia, R. C. Lanza, S. Lo Meo, M. Lucentini, S. Majewski, R. Pani, R. Pellegrini, F. Santavenere, B. Tsui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Good spatial resolution and high sensitivity are required for detectors to be used for most of the bio-medical research and application (small animal imaging, detection of small tumors,). In this paper we report on parameter optimization of single photon gamma rays detectors. Simulations and measurements were performed for designing and building detectors for early detection of small tumors in breast and in small animal imaging. Critical parameters are: Contrast and Signal to Noise Ratio (SNR). Intrinsic performances (spatial resolution, pixel identification etc.) were optimized first. Arrays of scintillators (NaI(Tl)) of different pixel pitch (down to the present technological limits for NaI(Tl) arrays fabrication (pitch of 2 × 2 mm2,1.5 × 1.5 mm2 and 1.2 × 1.2 mm 2)) were coupled to arrays of PSPMTs with two anode readout element dimensions (6 × 6 mm2 and 3 × 3 mm2). Detectors having Field Of View of 100 × 100 mm2 and 150 × 200 mm2 were designed and built. An electronics system for reading out all the anode pad signals has been designed and constructed. Finally the collimation technique was considered. The limits of the coded aperture option have been studied. Preliminary results of these studies are presented.

Original languageEnglish (US)
Title of host publication2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
Pages2811-2814
Number of pages4
DOIs
StatePublished - Dec 1 2005
EventNuclear Science Symposium Conference Record, 2005 IEEE - , Puerto Rico
Duration: Oct 23 2005Oct 29 2005

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume5
ISSN (Print)1095-7863

Other

OtherNuclear Science Symposium Conference Record, 2005 IEEE
CountryPuerto Rico
Period10/23/0510/29/05

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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    Garibaldi, F., Accorsi, R., Cinti, M. N., Cisbani, E., Colilli, S., Cusanno, F., Fratoni, R., Giuliani, F., Gricia, M., Lanza, R. C., Lo Meo, S., Lucentini, M., Majewski, S., Pani, R., Pellegrini, R., Santavenere, F., & Tsui, B. (2005). High resolution and high sensitivity detectors for functional molecular imaging with radionuclides: The role of scintillator pixel size, photodetector anode pitch, collimation technique, and of the readout. In 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference (pp. 2811-2814). [1596919] (IEEE Nuclear Science Symposium Conference Record; Vol. 5). https://doi.org/10.1109/NSSMIC.2005.1596919