High prevalence of thrombophilic traits in children with family history of thromboembolism

Meghan J. Calhoon, Cassie N. Ross, Elizabeth Pounder, Danielle Cassidy, Marilyn J. Manco-Johnson, Neil A. Goldenberg

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To determine a proximate family history of venous thromboembolism (VTE) in (1) the prevalence of thrombophilia; (2) the frequency of recommended changes in management resulting from thrombophilia evaluation; and (3) outcomes in longitudinal follow-up. Study design: Laboratory thrombophilia investigation was performed in 56 children with first- or second-degree family history of thromboembolism before age 55 years, but without personal history of thromboembolism, who were enrolled in a prospective inception cohort. VTE risk factors, family history, thrombophilia findings, and management recommendations were systematically collected, along with thromboembolism risk episodes/exposures, prophylactic anticoagulation, major bleeds, and thromboembolism events during follow-up. Results: The frequencies of all thrombophilia traits were higher than the general population. Among 32 children who underwent complete laboratory evaluation, 34% had ≥2 traits. Thrombophilia testing led to recommendations for risk-based transient antithrombotic prophylaxis in 71% of subjects. No thromboembolism episodes developed during more than 900 patient-months of follow-up, although at-risk exposures were infrequent. Conclusion: Risk-stratified approaches to primary prevention of pediatric VTE should be further evaluated in cooperative prospective studies.

Original languageEnglish (US)
Pages (from-to)485-489
Number of pages5
JournalJournal of Pediatrics
Volume157
Issue number3
DOIs
StatePublished - Sep 2010

Keywords

  • APA
  • Antiphospholipid antibody
  • ELISA
  • Enzyme-linked immunosorbent assay
  • FVIII
  • Factor VIII
  • IgG
  • IgM
  • Immunoglobulin G
  • Immunoglobulin M
  • OCP
  • Oral contraceptive pills
  • VTE
  • Venous thromboembolism

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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