High prevalence of hepatitis delta virus among patients with chronic hepatitis B Virus infection and HIV-1 in an intermediate hepatitis B virus endemic region

Shanmugam Saravanan, Vidya Madhavan, Vijayakumar Velu, Kailapuri G. Murugavel, Greer Waldrop, Sunil S. Solomon, Pachamuthu Balakrishnan, Nagalingeswaran Kumarasamy, Davey M. Smith, Kenneth H. Mayer, Suniti Solomon, Sadras P. Thyagarajan

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a study to investigate HIV and hepatitis delta virus (HDV) coinfection among patients with chronic hepatitis B virus (HBV) infection and the triple infection's (HIV/HBV/HDV) clinical implications in India, an intermediate HBV endemic region, with an estimated HIV-positive population of 2.5 million. A total of 450 patients (men: 270; women: 180) with chronic HBV infections and 135 healthy volunteers were screened for HIV and HDV. The incidence of the triple infection was low (4 [0.8%]) compared with dual infections of HIV-1/HBV (7 [1.5%]) and HBV/HDV (22[4.8%]). Among 21- to 40-year-olds, HBV/HDV coinfection (45.8%) and HBV/HDV/HIV-1 triple infection was predominant (75%). Among 11 patients coinfected with HIV-1/HBV, 4 (36%) were tri-infected and were also associated with chronic hepatitis and cirrhosis. The HDV coinfection was higher among patients coinfected with HBV/HIV-1, despite the declining trend in HDV infection among HIV-negative patients, as previously reported. Thus, it is important to assess the impact of HIV, chronic HBV, and HDV tri-infection in India.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalJournal of the International Association of Providers of AIDS Care
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • coinfection in India
  • hepatitis B virus (HBV)
  • hepatitis delta virus (HDV)
  • human immunodeficiency virus (HIV)

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

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