High prevalence of hepatitis delta virus among patients with chronic hepatitis B Virus infection and HIV-1 in an intermediate hepatitis B virus endemic region

Shanmugam Saravanan, Vidya Madhavan, Vijayakumar Velu, Kailapuri G. Murugavel, Greer Waldrop, Sunil Solomon, Pachamuthu Balakrishnan, Nagalingeswaran Kumarasamy, Davey M. Smith, Kenneth H. Mayer, Suniti Solomon, Sadras P. Thyagarajan

Research output: Contribution to journalArticle

Abstract

We conducted a study to investigate HIV and hepatitis delta virus (HDV) coinfection among patients with chronic hepatitis B virus (HBV) infection and the triple infection's (HIV/HBV/HDV) clinical implications in India, an intermediate HBV endemic region, with an estimated HIV-positive population of 2.5 million. A total of 450 patients (men: 270; women: 180) with chronic HBV infections and 135 healthy volunteers were screened for HIV and HDV. The incidence of the triple infection was low (4 [0.8%]) compared with dual infections of HIV-1/HBV (7 [1.5%]) and HBV/HDV (22[4.8%]). Among 21- to 40-year-olds, HBV/HDV coinfection (45.8%) and HBV/HDV/HIV-1 triple infection was predominant (75%). Among 11 patients coinfected with HIV-1/HBV, 4 (36%) were tri-infected and were also associated with chronic hepatitis and cirrhosis. The HDV coinfection was higher among patients coinfected with HBV/HIV-1, despite the declining trend in HDV infection among HIV-negative patients, as previously reported. Thus, it is important to assess the impact of HIV, chronic HBV, and HDV tri-infection in India.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalJournal of the International Association of Providers of AIDS Care
Volume13
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Fingerprint

Hepatitis Delta Virus
Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
HIV-1
HIV
Coinfection
India
Infection
Hepatitis D
Chronic Hepatitis
HIV Infections
Healthy Volunteers
Fibrosis

Keywords

  • coinfection in India
  • hepatitis B virus (HBV)
  • hepatitis delta virus (HDV)
  • human immunodeficiency virus (HIV)

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

Cite this

High prevalence of hepatitis delta virus among patients with chronic hepatitis B Virus infection and HIV-1 in an intermediate hepatitis B virus endemic region. / Saravanan, Shanmugam; Madhavan, Vidya; Velu, Vijayakumar; Murugavel, Kailapuri G.; Waldrop, Greer; Solomon, Sunil; Balakrishnan, Pachamuthu; Kumarasamy, Nagalingeswaran; Smith, Davey M.; Mayer, Kenneth H.; Solomon, Suniti; Thyagarajan, Sadras P.

In: Journal of the International Association of Providers of AIDS Care, Vol. 13, No. 1, 01.2014, p. 85-90.

Research output: Contribution to journalArticle

Saravanan, S, Madhavan, V, Velu, V, Murugavel, KG, Waldrop, G, Solomon, S, Balakrishnan, P, Kumarasamy, N, Smith, DM, Mayer, KH, Solomon, S & Thyagarajan, SP 2014, 'High prevalence of hepatitis delta virus among patients with chronic hepatitis B Virus infection and HIV-1 in an intermediate hepatitis B virus endemic region', Journal of the International Association of Providers of AIDS Care, vol. 13, no. 1, pp. 85-90. https://doi.org/10.1177/2325957413488166
Saravanan, Shanmugam ; Madhavan, Vidya ; Velu, Vijayakumar ; Murugavel, Kailapuri G. ; Waldrop, Greer ; Solomon, Sunil ; Balakrishnan, Pachamuthu ; Kumarasamy, Nagalingeswaran ; Smith, Davey M. ; Mayer, Kenneth H. ; Solomon, Suniti ; Thyagarajan, Sadras P. / High prevalence of hepatitis delta virus among patients with chronic hepatitis B Virus infection and HIV-1 in an intermediate hepatitis B virus endemic region. In: Journal of the International Association of Providers of AIDS Care. 2014 ; Vol. 13, No. 1. pp. 85-90.
@article{161e67e17a4144f4861314403c06eace,
title = "High prevalence of hepatitis delta virus among patients with chronic hepatitis B Virus infection and HIV-1 in an intermediate hepatitis B virus endemic region",
abstract = "We conducted a study to investigate HIV and hepatitis delta virus (HDV) coinfection among patients with chronic hepatitis B virus (HBV) infection and the triple infection's (HIV/HBV/HDV) clinical implications in India, an intermediate HBV endemic region, with an estimated HIV-positive population of 2.5 million. A total of 450 patients (men: 270; women: 180) with chronic HBV infections and 135 healthy volunteers were screened for HIV and HDV. The incidence of the triple infection was low (4 [0.8{\%}]) compared with dual infections of HIV-1/HBV (7 [1.5{\%}]) and HBV/HDV (22[4.8{\%}]). Among 21- to 40-year-olds, HBV/HDV coinfection (45.8{\%}) and HBV/HDV/HIV-1 triple infection was predominant (75{\%}). Among 11 patients coinfected with HIV-1/HBV, 4 (36{\%}) were tri-infected and were also associated with chronic hepatitis and cirrhosis. The HDV coinfection was higher among patients coinfected with HBV/HIV-1, despite the declining trend in HDV infection among HIV-negative patients, as previously reported. Thus, it is important to assess the impact of HIV, chronic HBV, and HDV tri-infection in India.",
keywords = "coinfection in India, hepatitis B virus (HBV), hepatitis delta virus (HDV), human immunodeficiency virus (HIV)",
author = "Shanmugam Saravanan and Vidya Madhavan and Vijayakumar Velu and Murugavel, {Kailapuri G.} and Greer Waldrop and Sunil Solomon and Pachamuthu Balakrishnan and Nagalingeswaran Kumarasamy and Smith, {Davey M.} and Mayer, {Kenneth H.} and Suniti Solomon and Thyagarajan, {Sadras P.}",
year = "2014",
month = "1",
doi = "10.1177/2325957413488166",
language = "English (US)",
volume = "13",
pages = "85--90",
journal = "Journal of the International Association of Providers of AIDS Care",
issn = "2325-9574",
publisher = "SAGE Publications Inc.",
number = "1",

}

TY - JOUR

T1 - High prevalence of hepatitis delta virus among patients with chronic hepatitis B Virus infection and HIV-1 in an intermediate hepatitis B virus endemic region

AU - Saravanan, Shanmugam

AU - Madhavan, Vidya

AU - Velu, Vijayakumar

AU - Murugavel, Kailapuri G.

AU - Waldrop, Greer

AU - Solomon, Sunil

AU - Balakrishnan, Pachamuthu

AU - Kumarasamy, Nagalingeswaran

AU - Smith, Davey M.

AU - Mayer, Kenneth H.

AU - Solomon, Suniti

AU - Thyagarajan, Sadras P.

PY - 2014/1

Y1 - 2014/1

N2 - We conducted a study to investigate HIV and hepatitis delta virus (HDV) coinfection among patients with chronic hepatitis B virus (HBV) infection and the triple infection's (HIV/HBV/HDV) clinical implications in India, an intermediate HBV endemic region, with an estimated HIV-positive population of 2.5 million. A total of 450 patients (men: 270; women: 180) with chronic HBV infections and 135 healthy volunteers were screened for HIV and HDV. The incidence of the triple infection was low (4 [0.8%]) compared with dual infections of HIV-1/HBV (7 [1.5%]) and HBV/HDV (22[4.8%]). Among 21- to 40-year-olds, HBV/HDV coinfection (45.8%) and HBV/HDV/HIV-1 triple infection was predominant (75%). Among 11 patients coinfected with HIV-1/HBV, 4 (36%) were tri-infected and were also associated with chronic hepatitis and cirrhosis. The HDV coinfection was higher among patients coinfected with HBV/HIV-1, despite the declining trend in HDV infection among HIV-negative patients, as previously reported. Thus, it is important to assess the impact of HIV, chronic HBV, and HDV tri-infection in India.

AB - We conducted a study to investigate HIV and hepatitis delta virus (HDV) coinfection among patients with chronic hepatitis B virus (HBV) infection and the triple infection's (HIV/HBV/HDV) clinical implications in India, an intermediate HBV endemic region, with an estimated HIV-positive population of 2.5 million. A total of 450 patients (men: 270; women: 180) with chronic HBV infections and 135 healthy volunteers were screened for HIV and HDV. The incidence of the triple infection was low (4 [0.8%]) compared with dual infections of HIV-1/HBV (7 [1.5%]) and HBV/HDV (22[4.8%]). Among 21- to 40-year-olds, HBV/HDV coinfection (45.8%) and HBV/HDV/HIV-1 triple infection was predominant (75%). Among 11 patients coinfected with HIV-1/HBV, 4 (36%) were tri-infected and were also associated with chronic hepatitis and cirrhosis. The HDV coinfection was higher among patients coinfected with HBV/HIV-1, despite the declining trend in HDV infection among HIV-negative patients, as previously reported. Thus, it is important to assess the impact of HIV, chronic HBV, and HDV tri-infection in India.

KW - coinfection in India

KW - hepatitis B virus (HBV)

KW - hepatitis delta virus (HDV)

KW - human immunodeficiency virus (HIV)

UR - http://www.scopus.com/inward/record.url?scp=84893132565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893132565&partnerID=8YFLogxK

U2 - 10.1177/2325957413488166

DO - 10.1177/2325957413488166

M3 - Article

C2 - 23722085

AN - SCOPUS:84893132565

VL - 13

SP - 85

EP - 90

JO - Journal of the International Association of Providers of AIDS Care

JF - Journal of the International Association of Providers of AIDS Care

SN - 2325-9574

IS - 1

ER -