High prevalence and genetic diversity of hcv among hiv-1 infected people from various high-risk groups in china

Hong Shang, Ping Zhong, Jing Liu, Xiaoxu Han, Di Dai, Min Zhang, Ke Zhao, Rongzhen Xu, Xiao Fang Yu

Research output: Contribution to journalArticle

Abstract

Background: Co-infection with HIV-1 and HCV is a significant global public health problem and a major consideration for anti-HIV-1 treatment. HCV infection among HIV-1 positive people who are eligible for the newly launched nationwide anti-HIV-1 treatment program in China has not been well characterized. Methodology: A nationwide survey of HIV-1 positive injection drug uses (IDU), former paid blood donors (FBD), and sexually transmitted cases from multiple provinces including the four most affected provinces in China was conducted. HCV prevalence and genetic diversity were determined. We found that IDU and FBD have extremely high rates of HCV infection (97% and 93%, respectively). Surprisingly, people who acquired HIV-1 through sexual contact also had a higher rate of HCV infection (20%) than the general population. HIV-1 subtype and HCV genotypes were amazingly similar among FBD from multiple provinces stretching from Central to Northeast China. However, although patterns of overland trafficking of heroin and distinct HIV-1 subtypes could be detected among IDU, HCV genotypes of IDU were more diverse and exhibited significant regional differences. Conclusion: Emerging HIV-1 and HCV co-infection and possible sexual transmission of HCV in China require urgent prevention measures and should be taken into consideration in the nationwide antiretroviral treatment program.

Original languageEnglish (US)
Article numbere10631
JournalPLoS One
Volume5
Issue number5
DOIs
StatePublished - 2010

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risk groups
Human immunodeficiency virus 1
HIV-1
China
genetic variation
drug injection
Blood
Pharmaceutical Preparations
Blood Donors
Heroin
Injections
Public health
Medical problems
Stretching
Coinfection
mixed infection
blood
Infection
Genotype
infection

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

High prevalence and genetic diversity of hcv among hiv-1 infected people from various high-risk groups in china. / Shang, Hong; Zhong, Ping; Liu, Jing; Han, Xiaoxu; Dai, Di; Zhang, Min; Zhao, Ke; Xu, Rongzhen; Yu, Xiao Fang.

In: PLoS One, Vol. 5, No. 5, e10631, 2010.

Research output: Contribution to journalArticle

Shang, H, Zhong, P, Liu, J, Han, X, Dai, D, Zhang, M, Zhao, K, Xu, R & Yu, XF 2010, 'High prevalence and genetic diversity of hcv among hiv-1 infected people from various high-risk groups in china', PLoS One, vol. 5, no. 5, e10631. https://doi.org/10.1371/journal.pone.0010631
Shang, Hong ; Zhong, Ping ; Liu, Jing ; Han, Xiaoxu ; Dai, Di ; Zhang, Min ; Zhao, Ke ; Xu, Rongzhen ; Yu, Xiao Fang. / High prevalence and genetic diversity of hcv among hiv-1 infected people from various high-risk groups in china. In: PLoS One. 2010 ; Vol. 5, No. 5.
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AU - Dai, Di

AU - Zhang, Min

AU - Zhao, Ke

AU - Xu, Rongzhen

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