High plasma norepinephrine levels in patients with major affective disorder

C. R. Lake, D. Pickar, M. G. Ziegler, S. Lipper, S. Slater, D. L. Murphy

Research output: Contribution to journalArticle

Abstract

The authors found that patients with major affective disorder had higher levels of plasma norepinephrine and higher pulse rates (tachycardia) than healthy control subjects, but their blood pressures were normal. These measurements were similar in all three subgroups of patients with affective disorder - manic, bipolar depressed, and unipolar. Because norepinephrine is the primary neurotransmitter of the sympathetic nervous system, these data suggest sympathetic hyperactivity in the major affective disorders. This conclusion is compatible with recent speculation based on the effect of antidepressants on noradrenergic receptors and a failure of α-receptors to downregulate normally in patients with major affective disorder.

Original languageEnglish (US)
Pages (from-to)1315-1318
Number of pages4
JournalAmerican Journal of Psychiatry
Volume139
Issue number10
StatePublished - 1982
Externally publishedYes

Fingerprint

Mood Disorders
Norepinephrine
Sympathetic Nervous System
Tachycardia
Antidepressive Agents
Neurotransmitter Agents
Healthy Volunteers
Down-Regulation
Heart Rate
Blood Pressure

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Lake, C. R., Pickar, D., Ziegler, M. G., Lipper, S., Slater, S., & Murphy, D. L. (1982). High plasma norepinephrine levels in patients with major affective disorder. American Journal of Psychiatry, 139(10), 1315-1318.

High plasma norepinephrine levels in patients with major affective disorder. / Lake, C. R.; Pickar, D.; Ziegler, M. G.; Lipper, S.; Slater, S.; Murphy, D. L.

In: American Journal of Psychiatry, Vol. 139, No. 10, 1982, p. 1315-1318.

Research output: Contribution to journalArticle

Lake, CR, Pickar, D, Ziegler, MG, Lipper, S, Slater, S & Murphy, DL 1982, 'High plasma norepinephrine levels in patients with major affective disorder', American Journal of Psychiatry, vol. 139, no. 10, pp. 1315-1318.
Lake CR, Pickar D, Ziegler MG, Lipper S, Slater S, Murphy DL. High plasma norepinephrine levels in patients with major affective disorder. American Journal of Psychiatry. 1982;139(10):1315-1318.
Lake, C. R. ; Pickar, D. ; Ziegler, M. G. ; Lipper, S. ; Slater, S. ; Murphy, D. L. / High plasma norepinephrine levels in patients with major affective disorder. In: American Journal of Psychiatry. 1982 ; Vol. 139, No. 10. pp. 1315-1318.
@article{10dea72e9b2547ceba48bcda7ccbcd4d,
title = "High plasma norepinephrine levels in patients with major affective disorder",
abstract = "The authors found that patients with major affective disorder had higher levels of plasma norepinephrine and higher pulse rates (tachycardia) than healthy control subjects, but their blood pressures were normal. These measurements were similar in all three subgroups of patients with affective disorder - manic, bipolar depressed, and unipolar. Because norepinephrine is the primary neurotransmitter of the sympathetic nervous system, these data suggest sympathetic hyperactivity in the major affective disorders. This conclusion is compatible with recent speculation based on the effect of antidepressants on noradrenergic receptors and a failure of α-receptors to downregulate normally in patients with major affective disorder.",
author = "Lake, {C. R.} and D. Pickar and Ziegler, {M. G.} and S. Lipper and S. Slater and Murphy, {D. L.}",
year = "1982",
language = "English (US)",
volume = "139",
pages = "1315--1318",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "10",

}

TY - JOUR

T1 - High plasma norepinephrine levels in patients with major affective disorder

AU - Lake, C. R.

AU - Pickar, D.

AU - Ziegler, M. G.

AU - Lipper, S.

AU - Slater, S.

AU - Murphy, D. L.

PY - 1982

Y1 - 1982

N2 - The authors found that patients with major affective disorder had higher levels of plasma norepinephrine and higher pulse rates (tachycardia) than healthy control subjects, but their blood pressures were normal. These measurements were similar in all three subgroups of patients with affective disorder - manic, bipolar depressed, and unipolar. Because norepinephrine is the primary neurotransmitter of the sympathetic nervous system, these data suggest sympathetic hyperactivity in the major affective disorders. This conclusion is compatible with recent speculation based on the effect of antidepressants on noradrenergic receptors and a failure of α-receptors to downregulate normally in patients with major affective disorder.

AB - The authors found that patients with major affective disorder had higher levels of plasma norepinephrine and higher pulse rates (tachycardia) than healthy control subjects, but their blood pressures were normal. These measurements were similar in all three subgroups of patients with affective disorder - manic, bipolar depressed, and unipolar. Because norepinephrine is the primary neurotransmitter of the sympathetic nervous system, these data suggest sympathetic hyperactivity in the major affective disorders. This conclusion is compatible with recent speculation based on the effect of antidepressants on noradrenergic receptors and a failure of α-receptors to downregulate normally in patients with major affective disorder.

UR - http://www.scopus.com/inward/record.url?scp=0019980531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019980531&partnerID=8YFLogxK

M3 - Article

C2 - 6289682

AN - SCOPUS:0019980531

VL - 139

SP - 1315

EP - 1318

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 10

ER -