High-performance dual-energy imaging with a flat-panel detector: Imaging physics from blackboard to benchtop to bedside

J. H. Siewerdsen, N. A. Shkumat, A. C. Dhanantwari, D. B. Williams, S. Richard, M. J. Daly, N. S. Paul, D. J. Moseley, D. A. Jaffray, J. Yorkston, R. Van Metter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The application of high-performance flat-panel detectors (FPDs) to dual-energy (DE) imaging offers the potential for dramatically improved detection and characterization of subtle lesions through reduction of "anatomical noise," with applications ranging from thoracic imaging to image-guided interventions. In this work, we investigate DE imaging performance from first principles of image science to preclinical implementation, including: 1.) generalized task-based formulation of NEQ and detectability as a guide to system optimization; 2.) measurements of imaging performance on a DE imaging benchtop; and 3.) a preclinical system developed in our laboratory for cardiac-gated DE chest imaging in a research cohort of 160 patients. Theoretical and benchtop studies directly guide clinical implementation, including the advantages of double-shot versus single-shot DE imaging, the value of differential added filtration between low- and high-kVp projections, and optimal selection of kVp pairs, filtration, and dose allocation. Evaluation of task-based NEQ indicates that the detectabiliry of subtle lung nodules in double-shot DE imaging can exceed that of single-shot DE imaging by a factor of 4 or greater. Filter materials are investigated that not only harden the high-kVp beam (e.g., Cu or Ag) but also soften the low-kVp beam (e.g., Ce or Gd), leading to significantly increased contrast in DE images. A preclinical imaging system suitable for human studies has been constructed based upon insights gained from these theoretical and experimental studies. An important component of the system is a simple and robust means of cardiacgated DE image acquisition, implemented here using a fingertip pulse oximeter. Timing schemes that provide cardiacgated image acquisition on the same or successive heartbeats is described. Preclinical DE images to be acquired under research protocol will afford valuable testing of optimal deployment, facilitate the development of DE CAD, and support comparison of DE diagnostic imaging performance to low-dose CT and radiography.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2006
Subtitle of host publicationPhysics of Medical Imaging
PublisherSPIE
ISBN (Print)0819461857, 9780819461858
DOIs
StatePublished - Jan 1 2006
Externally publishedYes
EventMedical Imaging 2006: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 12 2006Feb 16 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6142 I
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2006: Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/12/062/16/06

Keywords

  • Cardiac gating
  • Detectability index
  • Dual-energy imaging
  • Flat-panel detector
  • Image-guided interventions
  • Imaging task
  • Noise-equivalent quanta
  • Thoracic imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Siewerdsen, J. H., Shkumat, N. A., Dhanantwari, A. C., Williams, D. B., Richard, S., Daly, M. J., Paul, N. S., Moseley, D. J., Jaffray, D. A., Yorkston, J., & Van Metter, R. (2006). High-performance dual-energy imaging with a flat-panel detector: Imaging physics from blackboard to benchtop to bedside. In Medical Imaging 2006: Physics of Medical Imaging [61421E] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6142 I). SPIE. https://doi.org/10.1117/12.658080