High-Osmolality and Low-Osmolality Contrast Agents

Sven Paulin, Edward W. Gertz, John Rudoff, Lavonne Phillips, Earl P. Steinberg, Richard D. Moore, Neil R. Powe, Ramana Gopalan, Jeffrey A. Brinker, Patrick S. Parfrey, Brendan J. Barrett

Research output: Contribution to journalLetterpeer-review


To the Editor: The publication of the articles by Steinberg et al. and Barrett et al. (Feb. 13 issue)1 , 2 comparing different radiographic contrast agents for invasive cardiac examinations demonstrates again the inability of such clinical studies to provide conclusive answers. Hemodynamic reactions to angiographic contrast agents have different components and vary widely with the form of administration.3 When a conventional high-osmolality agent is injected selectively into the coronary artery of a dog,4 a transient profound depression of myocardial contractility results, whereas the nonionic medium at an equal dose and iodine content hardly elicits a detectable change in left ventricular pressure…

Original languageEnglish (US)
Pages (from-to)202-205
Number of pages4
JournalNew England Journal of Medicine
Issue number3
StatePublished - Jul 16 1992

ASJC Scopus subject areas

  • Medicine(all)


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