High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa

Infant HIV Drug Resistance Survey Team

doi:10.1097/QAD.0000000000002580

High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa

Infant HIV Drug Resistance Survey Team

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

: Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.

Original language	English (US)
Pages (from-to)	1567-1570
Number of pages	4
Journal	AIDS (London, England)
Volume	34
Issue number	10
DOIs	https://doi.org/10.1097/QAD.0000000000002580
State	Published - Aug 1 2020

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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@article{e8954bec8eed4c51bcea8d32fb63055c,

title = "High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa",

abstract = ": Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.",

author = "{Infant HIV Drug Resistance Survey Team} and Inzaule, {Seth C.} and Jordan, {Michael R.} and George Bello and Nellie Wadonda-Kabondo and Salou Mounerou and Mbulli, {Innocent A.} and Akanmu, {Sulaimon A.} and Adolfo Vubil and Gillian Hunt and Pontiano Kaleebu and Simangele Mthethwa-Hleza and Janet Dzangare and Patrick Njukeng and Martina Penazzato and {Rinke de Wit}, {Tobias F.} and Eshleman, {Susan H.} and Silvia Bertagnolio",

note = "Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine",

year = "2020",

month = aug,

day = "1",

doi = "10.1097/QAD.0000000000002580",

language = "English (US)",

volume = "34",

pages = "1567--1570",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "10",

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TY - JOUR

T1 - High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa

AU - Infant HIV Drug Resistance Survey Team

AU - Inzaule, Seth C.

AU - Jordan, Michael R.

AU - Bello, George

AU - Wadonda-Kabondo, Nellie

AU - Mounerou, Salou

AU - Mbulli, Innocent A.

AU - Akanmu, Sulaimon A.

AU - Vubil, Adolfo

AU - Hunt, Gillian

AU - Kaleebu, Pontiano

AU - Mthethwa-Hleza, Simangele

AU - Dzangare, Janet

AU - Njukeng, Patrick

AU - Penazzato, Martina

AU - Rinke de Wit, Tobias F.

AU - Eshleman, Susan H.

AU - Bertagnolio, Silvia

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2020/8/1

Y1 - 2020/8/1

N2 - : Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.

AB - : Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.

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U2 - 10.1097/QAD.0000000000002580

DO - 10.1097/QAD.0000000000002580

M3 - Article

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VL - 34

SP - 1567

EP - 1570

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 10

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