High Intercorrelations Among Urinary Outputs of Norepinephrine and Its Major Metabolites: A Replication in Depressed Patients and Controls

Alec Roy, Sally Guthrie, Farouk Karoum, David Pickar, Markku Linnoila

Research output: Contribution to journalArticle

Abstract

We examined the intercorrelations among urinary outputs of norepinephrine (NE) and its three major metabolites in unipolar depressed patients (n = 28) and normal controls (n = 24). Among the depressed patients, levels of NE correlated with normetanephrine (NM), 3-methoxy-4-hydroxyphenylglycol (MHPG), and vanillylmandelic acid (VMA), and VMA correlated with NM and MHPG. In the total group of depressed and control subjects (n = 52), the sum of NE and its major metabolites correlated with urinary outputs of NE, NM, MHPG, and VMA. These highly significant correlations among urinary outputs of NE and its major metabolites replicate a previous report of strong correlations among these same four urinary substances in a smaller group of depressed patients.

Original languageEnglish (US)
Pages (from-to)158-161
Number of pages4
JournalArchives of General Psychiatry
Volume45
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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