High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population

Audrey V. Grant, Maria Ilma Araujo, Eduardo Vieira Ponte, Ricardo Riccio Oliveira, Alvaro A. Cruz, Kathleen C. Barnes, Terri L Beaty

Research output: Contribution to journalArticle

Abstract

Background. Evidence of genetic control for total serum IgE (tIgE) level has been reported in multiple populations, although populations with substantial exposure to helminths have yielded lower estimates of heritability, despite evidence suggesting that genes also control a significant portion of the variation in the number of Schistosoma mansoni eggs per gram of fecal matter. Methods. By use of a whole-population ascertainment scheme, 822 individuals were enrolled from a schistosomiasis-endemic area in Conde, Bahia, in Brazil. Heritability was estimated by using an additive polygenic model, and segregation analysis was performed for 2 quantitative traits, tIgE level and egg count. Results. After adjusting for nongenetic covariates, the heritability of log-transformed tIgE level and log-transformed egg count was estimated at 60% and 31%, respectively. No evidence for a single major gene controlling tIgE level or egg count was observed in segregation analysis for 781 individuals and 403 individuals, respectively, in 318 families, however, which suggests complex biological control. Conclusions. The high heritability of tIgE level indicates that genetic factors are likely to control tIgE level even in the presence of helminthic infection. Substantial heritability for the burden of S. mansoni infection was confirmed in these Brazilian families. Further genetic studies will be needed to dissect the specific genetic factors that underlie these traits.

Original languageEnglish (US)
Pages (from-to)1227-1236
Number of pages10
JournalJournal of Infectious Diseases
Volume198
Issue number8
DOIs
StatePublished - Oct 15 2008

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Schistosomiasis mansoni
Schistosomiasis
Immunoglobulin E
Serum
Population
Ovum
Schistosoma mansoni
Helminths
Eggs
Genes
Brazil
Infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

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High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population. / Grant, Audrey V.; Araujo, Maria Ilma; Ponte, Eduardo Vieira; Oliveira, Ricardo Riccio; Cruz, Alvaro A.; Barnes, Kathleen C.; Beaty, Terri L.

In: Journal of Infectious Diseases, Vol. 198, No. 8, 15.10.2008, p. 1227-1236.

Research output: Contribution to journalArticle

Grant, Audrey V. ; Araujo, Maria Ilma ; Ponte, Eduardo Vieira ; Oliveira, Ricardo Riccio ; Cruz, Alvaro A. ; Barnes, Kathleen C. ; Beaty, Terri L. / High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population. In: Journal of Infectious Diseases. 2008 ; Vol. 198, No. 8. pp. 1227-1236.
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abstract = "Background. Evidence of genetic control for total serum IgE (tIgE) level has been reported in multiple populations, although populations with substantial exposure to helminths have yielded lower estimates of heritability, despite evidence suggesting that genes also control a significant portion of the variation in the number of Schistosoma mansoni eggs per gram of fecal matter. Methods. By use of a whole-population ascertainment scheme, 822 individuals were enrolled from a schistosomiasis-endemic area in Conde, Bahia, in Brazil. Heritability was estimated by using an additive polygenic model, and segregation analysis was performed for 2 quantitative traits, tIgE level and egg count. Results. After adjusting for nongenetic covariates, the heritability of log-transformed tIgE level and log-transformed egg count was estimated at 60{\%} and 31{\%}, respectively. No evidence for a single major gene controlling tIgE level or egg count was observed in segregation analysis for 781 individuals and 403 individuals, respectively, in 318 families, however, which suggests complex biological control. Conclusions. The high heritability of tIgE level indicates that genetic factors are likely to control tIgE level even in the presence of helminthic infection. Substantial heritability for the burden of S. mansoni infection was confirmed in these Brazilian families. Further genetic studies will be needed to dissect the specific genetic factors that underlie these traits.",
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