High-grade prostatic adenocarcinoma present in a single biopsy core is associated with increased extraprostatic extension, seminal vesicle invasion, and positive surgical margins at prostatectomy

Alcides Chaux, Daniel A. Fajardo, Nilda Gonzalez-Roibon, Alan Wayne Partin, Mario Eisenberger, Theodore DeWeese, George J. Netto

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the pathologic outcome of prostate-specific antigen-screened patients with high-grade (Gleason score ≥ 8) prostate cancer limited to 1 biopsy core, without clinical evidence of disease. Methods: Ninety-two patients with only 1 biopsy core with cancer and treated by radical prostatectomy were divided into 4 groups according to the biopsy Gleason score: 3 + 3 = 6 (23 cases), 3 + 4 = 7 (25 cases), 4 + 3 = 7 (20 cases), and ≥8 (24 cases). Results: Cases with Gleason score ≥8 showed a significantly higher proportion of extraprostatic extension (50%), positive surgical margins (21%), and seminal vesicle invasion (12%) when compared with the other groups. Patients with Gleason score ≥8 in the biopsy had a 25-fold increased in the odds ratio for extraprostatic extension in the prostatectomy. The incidence of extraprostatic extension was higher in those with prostatic cancer involving ≥50% of one core (88%) compared with cases involving

Original languageEnglish (US)
Pages (from-to)863-868
Number of pages6
JournalUrology
Volume79
Issue number4
DOIs
StatePublished - Apr 2012

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Neoplasm Grading
Seminal Vesicles
Prostatectomy
Adenocarcinoma
Biopsy
Prostatic Neoplasms
Prostate-Specific Antigen
Odds Ratio
Margins of Excision
Incidence
Neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

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title = "High-grade prostatic adenocarcinoma present in a single biopsy core is associated with increased extraprostatic extension, seminal vesicle invasion, and positive surgical margins at prostatectomy",
abstract = "Objective: To evaluate the pathologic outcome of prostate-specific antigen-screened patients with high-grade (Gleason score ≥ 8) prostate cancer limited to 1 biopsy core, without clinical evidence of disease. Methods: Ninety-two patients with only 1 biopsy core with cancer and treated by radical prostatectomy were divided into 4 groups according to the biopsy Gleason score: 3 + 3 = 6 (23 cases), 3 + 4 = 7 (25 cases), 4 + 3 = 7 (20 cases), and ≥8 (24 cases). Results: Cases with Gleason score ≥8 showed a significantly higher proportion of extraprostatic extension (50{\%}), positive surgical margins (21{\%}), and seminal vesicle invasion (12{\%}) when compared with the other groups. Patients with Gleason score ≥8 in the biopsy had a 25-fold increased in the odds ratio for extraprostatic extension in the prostatectomy. The incidence of extraprostatic extension was higher in those with prostatic cancer involving ≥50{\%} of one core (88{\%}) compared with cases involving",
author = "Alcides Chaux and Fajardo, {Daniel A.} and Nilda Gonzalez-Roibon and Partin, {Alan Wayne} and Mario Eisenberger and Theodore DeWeese and Netto, {George J.}",
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T1 - High-grade prostatic adenocarcinoma present in a single biopsy core is associated with increased extraprostatic extension, seminal vesicle invasion, and positive surgical margins at prostatectomy

AU - Chaux, Alcides

AU - Fajardo, Daniel A.

AU - Gonzalez-Roibon, Nilda

AU - Partin, Alan Wayne

AU - Eisenberger, Mario

AU - DeWeese, Theodore

AU - Netto, George J.

PY - 2012/4

Y1 - 2012/4

N2 - Objective: To evaluate the pathologic outcome of prostate-specific antigen-screened patients with high-grade (Gleason score ≥ 8) prostate cancer limited to 1 biopsy core, without clinical evidence of disease. Methods: Ninety-two patients with only 1 biopsy core with cancer and treated by radical prostatectomy were divided into 4 groups according to the biopsy Gleason score: 3 + 3 = 6 (23 cases), 3 + 4 = 7 (25 cases), 4 + 3 = 7 (20 cases), and ≥8 (24 cases). Results: Cases with Gleason score ≥8 showed a significantly higher proportion of extraprostatic extension (50%), positive surgical margins (21%), and seminal vesicle invasion (12%) when compared with the other groups. Patients with Gleason score ≥8 in the biopsy had a 25-fold increased in the odds ratio for extraprostatic extension in the prostatectomy. The incidence of extraprostatic extension was higher in those with prostatic cancer involving ≥50% of one core (88%) compared with cases involving

AB - Objective: To evaluate the pathologic outcome of prostate-specific antigen-screened patients with high-grade (Gleason score ≥ 8) prostate cancer limited to 1 biopsy core, without clinical evidence of disease. Methods: Ninety-two patients with only 1 biopsy core with cancer and treated by radical prostatectomy were divided into 4 groups according to the biopsy Gleason score: 3 + 3 = 6 (23 cases), 3 + 4 = 7 (25 cases), 4 + 3 = 7 (20 cases), and ≥8 (24 cases). Results: Cases with Gleason score ≥8 showed a significantly higher proportion of extraprostatic extension (50%), positive surgical margins (21%), and seminal vesicle invasion (12%) when compared with the other groups. Patients with Gleason score ≥8 in the biopsy had a 25-fold increased in the odds ratio for extraprostatic extension in the prostatectomy. The incidence of extraprostatic extension was higher in those with prostatic cancer involving ≥50% of one core (88%) compared with cases involving

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U2 - 10.1016/j.urology.2011.10.012

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